Maternal and preterm fetal sheep responses to dexmedetomidine.
Maternal and preterm fetal sheep responses to dexmedetomidine.
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DOI：
10.1016/j.ijoa.2012.06.010
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发表时间：
2012-10
影响因子：
2.8
通讯作者：
Reynolds JD
中科院分区：
文献类型：
--
作者：
Uemura K;Shimazutsu K;McClaine RJ;McClaine DJ;Manson RJ;White WD;Benni PB;Reynolds JD
The α2 adrenergic receptor agonist dexmedetomidine has some unique pharmacologic properties that could benefit pregnant patients (and their fetuses) when they require sedation, analgesia, and/or anesthesia during pregnancy. The purpose of the present study was to delineate maternal and fetal responses to an intravenous infusion of dexmedetomidine. This study was conducted on surgically-recovered preterm sheep instrumented for physiologic recording and blood sampling. Maternal and fetal cardiovascular and blood gas parameters and fetal cerebral oxygenation levels were recorded before, during, and after 3 h of dexmedetomidine infusion to the ewe at a rate of 1 μg/kg/h. Drug infusion produced overt sedation but no apparent respiratory depression as evidenced by stable maternal arterial blood gases; fetal blood gases were also stable. The one blood parameter to change was serum glucose, By the end of the 3 h infusion, glucose increased from 49 ± 10 to 104 ± 33 mg/dL in the ewe and from 22 ± 3 to 48 ± 16 mg/dL in the fetus; it declined post-drug exposure but remained elevated compared to the starting levels (maternal, 63 ± 12 mg/dL, P = 0.0497; and fetal, 24 ± 4 mg/dL, P = 0.012). With respect to cardiovascular status, dexmedetomidine produced a fall in maternal blood pressure and heart rate with fluctuations in uterine blood flow but had no discernable effect on fetal heart rate or mean arterial pressure. Likewise, maternal drug infusion had no effect on fetal cerebral oxygenation, as measured by in utero near-infrared spectroscopy. Using a clinically-relevant dosing regimen, intravenous infusion of dexmedetomidine produced significant maternal sedation without altering fetal physiologic status. Results from this initial acute assessment support the conduct of further studies to determine if dexmedetomidine has clinical utility for sedation and pain control during pregnancy.
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影响因子：
3.1
作者：
Gjelsteen, Andrew C.;Ching, Brian H.;Mitchell, Lex A.
通讯作者：
Mitchell, Lex A.
影响因子：
6.7
作者：
AHO, M;ERKOLA, O;KORTTILA, K
通讯作者：
KORTTILA, K
影响因子：
8.8
作者：
Drummond, John C.;Dao, Andrew V.;Patel, Piyush M.
通讯作者：
Patel, Piyush M.
DOI：
10.1016/0300-9629(91)90307-x
发表时间：
1991-01-01
期刊：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY
影响因子：
--
作者：
CISSIK, JH;EHLER, WJ;SNYDER, RR
通讯作者：
SNYDER, RR
影响因子：
2.1
作者：
AlaKokko, TI;Pienimaki, P;Vahakangas, K
通讯作者：
Vahakangas, K