Femtosecond Laser-Assisted Small Incision Allogeneic Endokeratophakia Using a Hyperopic Lenticule in Rabbits.
Femtosecond Laser-Assisted Small Incision Allogeneic Endokeratophakia Using a Hyperopic Lenticule in Rabbits.
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使用远视微透镜进行飞秒激光辅助小切口同种异体角膜内镜手术
DOI：
10.1167/tvst.10.12.29
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发表时间：
2021-10-04
影响因子：
3
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Han T;Shen Y;Shang J;Fu D;Zhao F;Zhao J;Li M;Zhou X
目的 使用小切口微透镜提取 (SMILE) 衍生的远视微透镜研究同种异体内角膜镜片术的形态学和组织病理学变化。方法 新西兰兔6只（12眼），随机均匀分为供体组和受体组。供体组进行双眼远视SMILE手术，受体组将凹面微透镜植入眼内。术后1天、1周、1个月、5个月进行角膜地形图和眼前节光学相干断层扫描（OCT）检查。手术后5个月，所有眼睛均被摘除。采用苏木精和伊红（HE）染色和透射电镜（TEM）观察受者组的角膜形态。结果 随访期间无并发症发生，角膜保持透明。术后1周内出现轻度角膜水肿。裂隙灯显微镜和OCT显示微透镜逐渐与周围的角膜基质融合。 HE染色显示角膜胶原排列规则。 HE染色和TEM可清晰识别微透镜与周围组织的边界，TEM下未发现炎症细胞。术后5个月角膜Km值较术前显着降低（P < 0.05）。结论 这项初步研究表明，同种异体远视 SMILE 微透镜内角膜镜片术似乎是安全可行的。转化相关性 同种异体远视 SMILE 透镜内角膜镜片术可适用于矫正角膜退行、扩张、超高近视或圆锥角膜。
Purpose To investigate the morphologic and histopathologic changes in allogeneic endokeratophakia using hyperopic lenticules derived from small-incision lenticule extraction (SMILE). Methods Six New Zealand rabbits (12 eyes) were included in this experiment and randomly and evenly divided into donor and recipient groups. The donor group underwent bilateral hyperopic SMILE surgery, and the concave lenticules were implanted into eyes in the recipient group. Corneal topography and anterior segment optical coherence tomography (OCT) examinations were performed at 1 day, 1 week, 1 month, and 5 months after surgery. All eyes were enucleated 5 months after surgery. Hematoxylin and eosin (HE) staining and transmission electron microscopy (TEM) were used to observe the corneal morphology in the recipient group. Results No complications were observed, and the corneas remained transparent in the follow-up period. There was mild corneal edema within 1 week after surgery. Slit-lamp microscopy and OCT showed that the lenticules were gradually integrated with the surrounding corneal stroma. HE staining showed that the arrangement of corneal collagen was regular. The boundary between the lenticules and surrounding tissue could be identified with HE staining and TEM, and no inflammatory cells were found under TEM. The corneal Km values were significantly lower at 5 months postoperatively compared to preoperatively (P < 0.05). Conclusions This pilot study showed that allogeneic hyperopic SMILE lenticule endokeratophakia seems to be safe and feasible. Translational Relevance Allogeneic hyperopic SMILE lenticule endokeratophakia may be applicable for the correction of corneal regression, ectasia, ultra-high myopia, or keratoconus.
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影响因子：
3.7
作者：
Lim CH;Riau AK;Lwin NC;Chaurasia SS;Tan DT;Mehta JS
通讯作者：
Mehta JS
添加同种异体微透镜和角膜交联治疗 LASIK 术后扩张后 30 个月的结果：病例报告
影响因子：
2
作者：
Li M;Yang D;Zhao F;Han T;Li M;Zhou X;Ni K
通讯作者：
Ni K
影响因子：
2.4
作者：
Sekundo, Walter;Messerschmidt-Roth, Anke;Blum, Marcus
通讯作者：
Blum, Marcus
影响因子：
4.4
作者：
Liu, Rui;Zhao, Jing;Zhou, Xingtao
通讯作者：
Zhou, Xingtao
DOI：
10.1007/s00417-017-3645-6
发表时间：
2017-06-01
影响因子：
2.7
作者：
Elaziz, Mohamed Samy Abd;Zaky, Adel Galal;El SaebaySarhan, Abdel Rahman
通讯作者：
El SaebaySarhan, Abdel Rahman