Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study.
Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study.
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原发中年 2 型糖尿病的决策：BOLD-fMRI 研究
DOI：
10.1038/s41598-017-10228-x
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发表时间：
2017-08-31
影响因子：
4.6
通讯作者：
Ma SH
中科院分区：
文献类型：
--
作者：
Sun DM;Ma Y;Sun ZB;Xie L;Huang JZ;Chen WS;Duan SX;Lin ZR;Guo RW;Le HB;Xu WC;Ma SH
虽然2型糖尿病(T2 DM)是公认的痴呆危险因素，但T2 DM认知损害的神经机制仍不清楚。我们在爱荷华州赌博任务的计算机化版本中使用了功能磁共振成像(FMRI)来研究T2 DM初始发病阶段决策的神经基础。18例新诊断的中年T2 DM患者，无糖尿病治疗史，与18例匹配的对照组。结果表明，T2 DM患者做出的不利决策多于对照组。与健康对照组相比，T2 DM患者前额叶腹侧皮质(VMPFC)、眶前叶皮质(OFC)和前扣带回皮质的激活程度降低，而背外侧前额叶、扣带回后叶、脑岛和枕叶的激活程度增加。两组IGT表现与VMPFC和OFC的脑激活变化呈正相关。此外，在患者的VMPFC和OFC中，血糖控制不良与行为和脑活动的决策功能有关。总而言之，至少IGT评估，T2 DM患者可能存在前额叶皮质功能缺陷，导致在模棱两可的情况下决策能力较差。
Although type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlying cognitive impairment in T2DM remain unclear. We used functional magnetic resonance imaging (fMRI) during a computerized version of the Iowa Gambling Task to investigate the neural basis of decision making at the initial onset stage of T2DM. Eighteen newly diagnosed middle-aged T2DM patients, with no previous diabetic treatment history, and 18 matched controls were recruited. Results indicated that T2DM patients made more disadvantageous decisions than controls. Compared to healthy subjects, T2DM patients showed decreased activation in the ventral medial prefrontal cortex (VMPFC), orbitofrontal cortex (OFC) and anterior cingulate cortex, and increased activity in the dorsolateral prefrontal cortex, posterior cingulate cortex, insula and occipital lobes. IGT performance positively correlated with changes in brain activation in the VMPFC and OFC in both groups. Moreover, poor glycemic control was associated with decision-making function both in behavioral and brain activity in the VMPFC and OFC in patients. Conclusively, T2DM patients may suffer from weaknesses in their prefrontal cortex functions that lead to poorer decision-making under ambiguity, at least as assessed by the IGT.
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影响因子：
1.1
作者：
Bechara, A;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
1.3
作者：
Lebeau, Gaele;Consoli, Silla M.;Lemogne, Cedric
通讯作者：
Lemogne, Cedric
影响因子：
3.1
作者：
Gonzalez-Reyes, Rodrigo E.;Aliev, Gjumrakch;Barreto, George E.
通讯作者：
Barreto, George E.
影响因子：
7.7
作者：
Hoogenboom WS;Marder TJ;Flores VL;Huisman S;Eaton HP;Schneiderman JS;Bolo NR;Simonson DC;Jacobson AM;Kubicki M;Shenton ME;Musen G
通讯作者：
Musen G
影响因子：
4.2
作者：
Kloeters, Silvie;Bertoux, Maxime;O'Callaghan, Claire;Hodges, John R.;Hornberger, Michael
通讯作者：
Hornberger, Michael