Cerebral white matter integrity and resting-state functional connectivity in middle-aged patients with type 2 diabetes.
Cerebral white matter integrity and resting-state functional connectivity in middle-aged patients with type 2 diabetes.
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作者：
Hoogenboom WS;Marder TJ;Flores VL;Huisman S;Eaton HP;Schneiderman JS;Bolo NR;Simonson DC;Jacobson AM;Kubicki M;Shenton ME;Musen G
在临床前阶段早期检测大脑异常可能有助于制定预防性干预措施，以减轻认知能力下降。我们研究了中年2型糖尿病患者是否表现出对认知重要的纤维束的白色完整性降低，以及这种异常是否与默认模式网络（DMN）中预先建立的静息状态功能连接改变有关。糖尿病和非糖尿病参与者进行扩散张量成像，功能磁共振成像和认知评估。多个扩散措施进行了计算，使用流线追踪，并确定与DMN功能连接的相关性。糖尿病患者在扣带束和钩束中表现出较低的各向异性分数（FA）（白色物质完整性的测量）。对照组显示出更强的功能连接比患者之间的后扣带回和左梭状回和内侧额回。对于联合组，扣带回束的FA与扣带回后回和额内侧回之间的功能连接相关。因此，中年2型糖尿病患者显示白色物质异常与DMN中的功能连接中断相关，这表明共同的机制可能是结构和功能连接的基础。在中年检测大脑异常可以实施治疗来减缓神经病理学的进展。
Early detection of brain abnormalities at the preclinical stage can be useful for developing preventive interventions to abate cognitive decline. We examined whether middle-aged type 2 diabetic patients show reduced white matter integrity in fiber tracts important for cognition and whether this abnormality is related to preestablished altered resting-state functional connectivity in the default mode network (DMN). Diabetic and nondiabetic participants underwent diffusion tensor imaging, functional magnetic resonance imaging, and cognitive assessment. Multiple diffusion measures were calculated using streamline tractography, and correlations with DMN functional connectivity were determined. Diabetic patients showed lower fractional anisotropy (FA) (a measure of white matter integrity) in the cingulum bundle and uncinate fasciculus. Control subjects showed stronger functional connectivity than patients between the posterior cingulate and both left fusiform and medial frontal gyri. FA of the cingulum bundle was correlated with functional connectivity between the posterior cingulate and medial frontal gyrus for combined groups. Thus, middle-aged patients with type 2 diabetes show white matter abnormalities that correlate with disrupted functional connectivity in the DMN, suggesting that common mechanisms may underlie structural and functional connectivity. Detecting brain abnormalities in middle age enables implementation of therapies to slow progression of neuropathology.
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影响因子：
7.7
作者：
Musen G;Jacobson AM;Bolo NR;Simonson DC;Shenton ME;McCartney RL;Flores VL;Hoogenboom WS
通讯作者：
Hoogenboom WS
影响因子：
8.2
作者：
Manschot, S. M.;Biessels, G. J.;de Valk, H.;Algra, A.;Rutten, G. E. H. M.;van der Grond, J.;Kappelle, L. J.
通讯作者：
Kappelle, L. J.
影响因子：
7.7
作者：
Musen, G;Lyoo, IK;Jacobson, AM
通讯作者：
Jacobson, AM
影响因子：
5.7
作者：
Friston, KJ;Stephan, KE;Kiebel, S
通讯作者：
Kiebel, S
影响因子：
4.5
作者：
Fitzsimmons, J.;Kubicki, M.;Smith, K.;Bushell, G.;Estepar, R. San Jose;Westin, C. -F.;Nestor, P. G.;Niznikiewicz, M. A.;Kikinis, R.;McCarley, R. W.;Shenton, M. E.
通讯作者：
Shenton, M. E.