Money for nothing - Atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease.
Money for nothing - Atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease.
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DOI：
10.1016/j.nicl.2013.01.011
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发表时间：
2013
影响因子：
4.2
通讯作者：
Hornberger, Michael
中科院分区：
文献类型：
--
作者：
Kloeters, Silvie;Bertoux, Maxime;O'Callaghan, Claire;Hodges, John R.;Hornberger, Michael
关键词：
神经退行性疾病患者经常表现出严重的日常决策问题。然而，目前尚不清楚哪些脑萎缩区域与此类决策问题有关。我们在63名参与者的样本中研究了赌博决策的萎缩相关性，包括两种神经退行性疾病（行为变异型额颞叶痴呆-bvFTD;阿尔茨海默病-AD）以及健康的年龄匹配对照。对所有参与者进行爱荷华州赌博任务（IGT）测试，并将行为IGT结果与所有参与者的T1 MRI扫描进行协变，以确定与赌博决策缺陷有关的脑萎缩区域。我们的研究结果表明，IGT表现的所有群体与两个患者组的表现特别差的任务有很大的差异。重要的是，bvFTD和AD组在IGT的行为表现方面无显著差异。然而，相比之下，bvFTD和AD之间的萎缩赌博决策相关性不同，bvFTD显示更多的额叶萎缩，AD显示更多的顶叶和颞叶萎缩，这与决策缺陷有关，表明两个患者组在不同程度上未能完成任务。额叶（额极，前扣带）和顶叶（压后）皮质萎缩与IGT表现不佳相关。总之，赌博决策的萎缩相关性表明，这种缺陷可能是由于不同神经结构的失败而发生的，这将为未来的诊断和治疗方案提供信息，以减轻神经退行性疾病患者的这些严重的日常问题。ADHD和AD患者在赌博决策方面均受损。然而，萎缩与赌博决策的相关性在各组之间存在差异。BvFTD患者决策能力差与额叶萎缩相关。AD患者决策能力差与顶叶/颞叶萎缩相关。赌博决策缺陷可能是由于不同大脑区域的萎缩而发生的。
Neurodegenerative patients show often severe everyday decision making problems. Currently it is however not clear which brain atrophy regions are implicated in such decision making problems. We investigated the atrophy correlates of gambling decision making in a sample of 63 participants, including two neurodegenerative conditions (behavioural variant frontotemporal dementia — bvFTD; Alzheimer's disease — AD) as well as healthy age-matched controls. All participants were tested on the Iowa Gambling Task (IGT) and the behavioural IGT results were covaried against the T1 MRI scans of all participants to identify brain atrophy regions implicated in gambling decision making deficits. Our results showed a large variability in IGT performance for all groups with both patient groups performing especially poor on the task. Importantly, bvFTD and AD groups did not differ significantly on the behavioural performance of the IGT. However, by contrast, the atrophy gambling decision making correlates differed between bvFTD and AD, with bvFTD showing more frontal atrophy and AD showing more parietal and temporal atrophy being implicated in decision making deficits, indicating that both patient groups fail the task on different levels. Frontal (frontopolar, anterior cingulate) and parietal (retrosplenial) cortex atrophy covaried with poor performance on the IGT. Taken together, the atrophy correlates of gambling decision making show that such deficits can occur due to a failure of different neural structures, which will inform future diagnostics and treatment options to alleviate these severe everyday problems in neurodegenerative patients. ► bvFTD and AD patients are both impaired in gambling decision making. ► However, atrophy correlates for gambling decision making differ between groups. ► Poor performance in decision making covaried with frontal atrophy in bvFTD. ► Poor performance in decision making covaried with parietal/temporal atrophy in AD. ► Gambling decision deficits can occur due to atrophy in different brain regions.
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影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
5.7
作者：
Baumann, Oliver;Mattingley, Jason B.
通讯作者：
Mattingley, Jason B.
DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
3.9
作者：
Giovagnoli, AR;Erbetta, A;Bugiani, O
通讯作者：
Bugiani, O
影响因子：
14.5
作者：
Daselaar, SM;Veltman, DJ;Jonker, C
通讯作者：
Jonker, C