Early life stress sensitizes individuals to the psychological correlates of mild fluctuations in inflammation.
Early life stress sensitizes individuals to the psychological correlates of mild fluctuations in inflammation.
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DOI：
10.1002/dev.21908
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发表时间：
2020-04
影响因子：
2.2
通讯作者：
Bower JE
中科院分区：
文献类型：
--
作者：
Kuhlman KR;Robles TF;Haydon MD;Dooley L;Boyle CC;Bower JE
早期生活压力（ELS）与人类一生中的健康差异有关，特别是抑郁症及其复发的风险增加。在这项研究中，我们探讨了两个合理的和竞争的途径，通过ELS可能导致抑郁症通过炎症。参与者（年龄18-22岁; n = 41）完成了早期创伤清单作为ELS的衡量标准。然后，参与者在接受年度流感疫苗接种前7天和接种后7天连续完成每日情绪和其他疾病行为日记。在接种前即刻和接种后24小时测量血浆白细胞介素-6（IL-6）的循环浓度。ELS与IL-6从接种疫苗前到接种疫苗后的变化幅度无关，然而，暴露于ELS缓和了IL-6从接种疫苗前到接种疫苗后的变化与认知困难和抑郁情绪变化之间的关联。暴露于更大ELS的个体对IL-6的增加表现出更大的心理敏感性。暴露于ELS可能会增加中枢神经系统对外周炎症的敏感性。需要进一步研究ELS对特定神经回路和细胞对炎症的敏感性的影响。
Early life stress (ELS) has been linked to health disparities across the human lifespan, particularly increased risk for depression and its recurrence. In this study we explore two plausible and competing pathways through which ELS may lead to depression via inflammation. Participants (ages 18–22; n = 41) completed the Early Trauma Inventory as a measure of ELS. Participants then completed consecutive daily diaries of mood and other sickness behavior for the 7 days prior to and 7 days after receiving the annual influenza vaccine. Circulating concentrations of plasma interleukin-6 (IL-6) were measured immediately before and 24 hr after vaccination. ELS was not associated with the magnitude of change in IL-6 from pre- to post-vaccine, however, exposure to ELS moderated the association between change in IL-6 from pre- to post-vaccine and changes in both cognitive difficulty and depressed mood. Individuals exposed to greater ELS showed greater psychological sensitivity to increases in IL-6. Exposure to ELS may increase sensitivity to peripheral inflammation in the central nervous system. Future studies elaborating on the impact of ELS on the sensitivity of specific neural circuits and cells to inflammation are needed.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
炎症在抑郁症的核心特征中的作用：使用外源引起的炎症从范式发出的见解。
影响因子：
8.2
作者：
Dooley LN;Kuhlman KR;Robles TF;Eisenberger NI;Craske MG;Bower JE
通讯作者：
Bower JE
DOI：
10.1161/01.atv.0000248534.30057.b5
发表时间：
2006-12-01
影响因子：
8.7
作者：
Carty, Cara L.;Heagerty, Patrick;Jarvik, Gail P.
通讯作者：
Jarvik, Gail P.
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
DOI：
10.1073/pnas.1218253109
发表时间：
2012-12-11
影响因子：
11.1
作者：
Cole, Steven W.;Conti, Gabriella;Suomi, Stephen J.
通讯作者：
Suomi, Stephen J.