Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships.
Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships.
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DOI：
10.1038/s41467-023-37460-6
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发表时间：
2023-04-29
影响因子：
16.6
通讯作者：
Liston, Conor
中科院分区：
文献类型：
--
作者：
Fetcho, Robert N.;Hall, Baila S.;Estrin, David J.;Walsh, Alexander P.;Schuette, Peter J.;Kaminsky, Jesse;Singh, Ashna;Roshgodal, Jacob;Bavley, Charlotte C.;Nadkarni, Viraj;Antigua, Susan;Huynh, Thu N.;Grosenick, Logan;Carthy, Camille;Komer, Lauren;Adhikari, Avishek;Lee, Francis S.;Rajadhyaksha, Anjali M.;Liston, Conor
社会等级制度对行为产生强大的影响，但检测和调节等级相互作用的神经生物学机制尚不清楚，特别是在神经回路层面。在这里，我们使用纤维光度测定和化学遗传学工具来记录和操纵试管测试社交竞赛期间腹内侧前额叶皮层（vmPFC-NAcSh）中伏隔核投射细胞的活动。我们发现，vmPFC-NAcSh 投射信号表明了习得的等级关系，并且当下级小鼠在遇到来自既定等级制度的主导竞争对手时发起努力的社会支配行为时，它们会被选择性地招募。在反复出现社交失败压力后，该回路在压力恢复个体发起的社交互动过程中优先被激活，并在支持服从小鼠的社交接近行为中发挥必要的作用。这些结果定义了 vmPFC-NAcSh 细胞在基于先前分层交互的社会交互行为的适应性调节中的必要作用。在这里，作者确定了一个额纹状体回路，该回路参与基于习得的层次关系调节社会互动。
Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at the level of neural circuits. Here, we use fiber photometry and chemogenetic tools to record and manipulate the activity of nucleus accumbens-projecting cells in the ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show that vmPFC-NAcSh projections signal learned hierarchical relationships, and are selectively recruited by subordinate mice when they initiate effortful social dominance behavior during encounters with a dominant competitor from an established hierarchy. After repeated bouts of social defeat stress, this circuit is preferentially activated during social interactions initiated by stress resilient individuals, and plays a necessary role in supporting social approach behavior in subordinated mice. These results define a necessary role for vmPFC-NAcSh cells in the adaptive regulation of social interaction behavior based on prior hierarchical interactions. Here, the authors identify a frontostriatal circuit that is involved in regulating social interactions based on learned hierarchical relationships.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
64.5
作者：
Hultman R;Ulrich K;Sachs BD;Blount C;Carlson DE;Ndubuizu N;Bagot RC;Parise EM;Vu MT;Gallagher NM;Wang J;Silva AJ;Deisseroth K;Mague SD;Caron MG;Nestler EJ;Carin L;Dzirasa K
通讯作者：
Dzirasa K
影响因子：
3.8
作者：
Bicks LK;Koike H;Akbarian S;Morishita H
通讯作者：
Morishita H
影响因子：
4.2
作者：
Johnson, Marcia K.;Nolen-Hoeksema, Susan;Levin, Yael
通讯作者：
Levin, Yael
星形胶质细胞衍生的 ATP 调节抑郁样行为
影响因子：
82.9
作者：
Cao, Xiong;Li, Liang-Ping;Gao, Tian-Ming
通讯作者：
Gao, Tian-Ming