MicroRNAs in the Onset of Schizophrenia.
MicroRNAs in the Onset of Schizophrenia.
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MicroRNAs在精神分裂症发病中的作用
DOI：
10.3390/cells10102679
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发表时间：
2021-10-06
期刊：
影响因子：
6
通讯作者：
Zakharenko SS
中科院分区：
文献类型：
--
作者：
Thomas KT;Zakharenko SS
越来越多的证据表明，microRNAs(MiRNAs)与精神分裂症的病理有关。这些小的非编码RNA与含有互补序列的mRNA结合，促进其降解和/或抑制蛋白质合成。一个miRNA可能有数百个靶点，而miRNA靶点在精神分裂症风险基因中的比例过高。虽然精神分裂症是一种神经发育障碍，但症状通常直到青春期才会出现，大多数患者直到青春期后期或成年早期才会得到精神分裂症的诊断。然而，很少有研究研究这一关键时期的miRNAs。首先，我们研究了miRNA途径在青春期和成年期是动态的证据，以及miRNAs调控精神分裂症患者后期神经发育的关键过程。接下来，我们研究了miRNAs与精神病转化有关的证据，包括MIR137HG中与精神分裂症相关的单核苷酸多态性，这是已知的预测精神分裂症患者发病年龄的最强指标之一。最后，我们研究了Dgcr8的半合性，它编码了合成miRNA前体的复合体的一个专有成分，可能有助于22q11.2微缺失患者的精神病的发生，以及这种疾病的动物模型如何帮助我们理解miRNAs在精神分裂症的发生中的许多作用。
Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia. These small noncoding RNAs bind to mRNAs containing complementary sequences and promote their degradation and/or inhibit protein synthesis. A single miRNA may have hundreds of targets, and miRNA targets are overrepresented among schizophrenia-risk genes. Although schizophrenia is a neurodevelopmental disorder, symptoms usually do not appear until adolescence, and most patients do not receive a schizophrenia diagnosis until late adolescence or early adulthood. However, few studies have examined miRNAs during this critical period. First, we examine evidence that the miRNA pathway is dynamic throughout adolescence and adulthood and that miRNAs regulate processes critical to late neurodevelopment that are aberrant in patients with schizophrenia. Next, we examine evidence implicating miRNAs in the conversion to psychosis, including a schizophrenia-associated single nucleotide polymorphism in MIR137HG that is among the strongest known predictors of age of onset in patients with schizophrenia. Finally, we examine how hemizygosity for DGCR8, which encodes an obligate component of the complex that synthesizes miRNA precursors, may contribute to the onset of psychosis in patients with 22q11.2 microdeletions and how animal models of this disorder can help us understand the many roles of miRNAs in the onset of schizophrenia.
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影响因子：
11.1
作者：
Arioka Y;Shishido E;Kushima I;Suzuki T;Saito R;Aiba A;Mori D;Ozaki N
通讯作者：
Ozaki N
DOI：
10.1016/j.devbrainres.2004.03.021
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bédard, A;Parent, A
通讯作者：
Parent, A
影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
6.6
作者：
BENES, FM
通讯作者：
BENES, FM
影响因子：
16.2
作者：
Bergmann, Olaf;Liebl, Jakob;Frisen, Jonas
通讯作者：
Frisen, Jonas