The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial.
The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial.
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热点干预措施对疟疾传播的影响：整群随机对照试验的研究方案。
DOI：
10.1186/1745-6215-14-36
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发表时间：
2013-02-02
期刊：
影响因子：
2.5
通讯作者：
Cox J
中科院分区：
文献类型：
--
作者：
Bousema T;Stevenson J;Baidjoe A;Stresman G;Griffin JT;Kleinschmidt I;Remarque EJ;Vulule J;Bayoh N;Laserson K;Desai M;Sauerwein R;Drakeley C;Cox J
在大多数情况下，疟疾传播具有高度异质性，导致形成了可识别的疟疾热点。如果这些热点地区助长疟疾向更广泛的社区传播，那么以这些热点地区为目标可能是控制或消除疟疾的一种非常有效的方式。疟疾热点将根据年龄调整的流行率和疟疾抗原顶端膜抗原-1和裂殖子表面蛋白-1抗体密度的空间模式来确定。将确定针对这些热点的干预措施的社区效果。干预措施将包括杀幼虫、人口重点筛查和治疗、分发长效驱虫蚊帐和室内滞留喷洒。干预措施的影响将确定内部和外部达500米的目标热点的PCR为基础的寄生虫患病率的横断面调查，疟疾发病率的被动病例检测在选定的设施和昆虫学监测的幼虫和成年按蚊种群。本研究旨在为针对热点的干预措施的社区效应提供直接证据。该试验旨在检测在正在进行的疟疾干预措施的背景下对疟疾传播的巨大影响。需要进行后续研究，以确定干预措施各个组成部分的效果以及针对热点的方法的成本效益，减少需要接受干预的化合物数量所节省的费用应超过热点检测的费用。NCT 01575613。该方案于2012年3月20日在线注册;第一个社区于2012年3月26日随机化。
Malaria transmission is highly heterogeneous in most settings, resulting in the formation of recognizable malaria hotspots. Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community. Hotspots of malaria will be determined based on spatial patterns in age-adjusted prevalence and density of antibodies against malaria antigens apical membrane antigen-1 and merozoite surface protein-1. The community effect of interventions targeted at these hotspots will be determined. The intervention will comprise larviciding, focal screening and treatment of the human population, distribution of long-lasting insecticide-treated nets and indoor residual spraying. The impact of the intervention will be determined inside and up to 500 m outside the targeted hotspots by PCR-based parasite prevalence in cross-sectional surveys, malaria morbidity by passive case detection in selected facilities and entomological monitoring of larval and adult Anopheles populations. This study aims to provide direct evidence for a community effect of hotspot-targeted interventions. The trial is powered to detect large effects on malaria transmission in the context of ongoing malaria interventions. Follow-up studies will be needed to determine the effect of individual components of the interventions and the cost-effectiveness of a hotspot-targeted approach, where savings made by reducing the number of compounds that need to receive interventions should outweigh the costs of hotspot-detection. NCT01575613. The protocol was registered online on 20 March 2012; the first community was randomized on 26 March 2012.
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影响因子：
3.3
作者：
Fillinger, U;Sonye, G;Becker, N
通讯作者：
Becker, N
影响因子：
--
作者：
Ghebreyesus, TA;Haile, M;Byass, P
通讯作者：
Byass, P
影响因子：
6.4
作者：
Bousema, Teun;Drakeley, Chris;Gosling, Roly
通讯作者：
Gosling, Roly
影响因子：
3.7
作者：
Cook, Jackie;Kleinschmidt, Immo;Drakeley, Chris J.
通讯作者：
Drakeley, Chris J.
DOI：
10.4269/ajtmh.1998.59.80
发表时间：
1998-07-01
影响因子：
3.3
作者：
Binka, FN;Indome, F;Smith, T
通讯作者：
Smith, T