Role of tonic GABAergic currents during pre- and early postnatal rodent development.
Role of tonic GABAergic currents during pre- and early postnatal rodent development.
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DOI：
10.3389/fncir.2013.00139
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发表时间：
2013
影响因子：
3.5
通讯作者：
Luhmann HJ
中科院分区：
文献类型：
--
作者：
Kilb W;Kirischuk S;Luhmann HJ
在过去的三十年中，很明显，GABA能系统通过影响神经元前体的增殖、神经元迁移和分化以及通过控制早期活动模式并因此形成神经元网络，对中枢神经系统的发育起着至关重要的作用。GABA通过激活离子型GABA受体后的去极化膜反应控制神经元发育。然而，这些效应中的许多发生在突触GABA能活性开始之前，因此需要在神经元前体和未成熟神经元中存在突触外紧张电流。本文综述了近年来有关紧张性GABA能电流在早期脑发育中的作用。本文就GABA受体亚基、GABA合成酶和GABA转运蛋白的表达时序和功能相关性进行了综述。我们还涉及GABAa受体的其他可能的内源性激动剂。此外，我们描述的功能性后果介导的GABA能系统在早期发育期间，并讨论目前的模型突触外GABA和/或其他内源性GABA能激动剂的起源在早期发育状态。最后，我们提出的证据表明，紧张性GABA能活动也是至关重要的参与生理以及病理生理活动模式的产生之前和之后的功能性GABA能突触连接的建立。
In the last three decades it became evident that the GABAergic system plays an essential role for the development of the central nervous system, by influencing the proliferation of neuronal precursors, neuronal migration and differentiation, as well as by controlling early activity patterns and thus formation of neuronal networks. GABA controls neuronal development via depolarizing membrane responses upon activation of ionotropic GABA receptors. However, many of these effects occur before the onset of synaptic GABAergic activity and thus require the presence of extrasynaptic tonic currents in neuronal precursors and immature neurons. This review summarizes our current knowledge about the role of tonic GABAergic currents during early brain development. In this review we compare the temporal sequence of the expression and functional relevance of different GABA receptor subunits, GABA synthesizing enzymes and GABA transporters. We also refer to other possible endogenous agonists of GABAA receptors. In addition, we describe functional consequences mediated by the GABAergic system during early developmental periods and discuss current models about the origin of extrasynaptic GABA and/or other endogenous GABAergic agonists during early developmental states. Finally, we present evidence that tonic GABAergic activity is also critically involved in the generation of physiological as well as pathophysiological activity patterns before and after the establishment of functional GABAergic synaptic connections.
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影响因子：
2.5
作者：
BARBIN, G;POLLARD, H;BENARI, Y
通讯作者：
BENARI, Y
影响因子：
5.3
作者：
Cancedda, Laura;Fiumelli, Hubert;Poo, Mu-ming
通讯作者：
Poo, Mu-ming
影响因子：
5.3
作者：
Achilles, Katharina;Okabe, Akihito;Kilb, Werner
通讯作者：
Kilb, Werner
影响因子：
3.3
作者：
COBAS, A;FAIREN, A;SANCHEZ, MP
通讯作者：
SANCHEZ, MP
影响因子：
5.3
作者：
Banke, Tue G.;McBain, Chris J.
通讯作者：
McBain, Chris J.