Body Mass Index and Overall Survival of Patients with Newly Diagnosed Multiple Myeloma.
Body Mass Index and Overall Survival of Patients with Newly Diagnosed Multiple Myeloma.
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越来越需要阐明可改变的生活方式因素（如肥胖）对多发性骨髓瘤（MM）结局的影响。在本文中，我们检查了新诊断出多发性骨髓瘤患者在诊断前不同生命阶段的体重指数（BMI）与总生存期之间的关系。关键发现是，诊断前和诊断时的BMI与MM的总生存期无关，除了诊断时较高的BMI与女性的总生存期较好相关，与人种/种族无关。这是第一个证据表明BMI与生存率的关系可能因性别而异。肥胖与几种实体瘤和非霍奇金淋巴瘤的生存率相关，但其对多发性骨髓瘤（MM）生存率的影响尚不清楚。我们研究了2010-2019年563例新诊断为MM的患者在诊断前不同生命阶段的体重指数（BMI）与总生存期（OS）之间的相关性。诊断时的BMI使用电子病历（EMR）中测量的身高和体重计算。使用自我报告的体重和EMR测量的身高计算20岁、成年期最大值和诊断前5年的BMI。中位随访时间为49.3个月，确定了191例（33.93%）死亡。我们使用多变量考克斯比例风险模型来检验BMI与OS之间的关系。身高以及诊断前和诊断时的BMI与OS无关，但体重与OS之间存在U型相关性。诊断时较高的BMI与女性较好的OS相关（HR = 0.39 [0.22-0.71]），与种族无关。总之，我们的研究结果表明，BMI在不同时期的生活，直到诊断的时间可能与OS在MM，除了诊断时较高的BMI与上级OS的女性。
There is a growing need to clarify the effect of modifiable lifestyle factors such as obesity on outcomes of multiple myeloma (MM). In this paper, we examined the associations between body mass index (BMI) at different periods of life up to the time of diagnosis and overall survival among patients newly diagnosed with multiple myeloma. The key findings are that BMIs before and at the time of diagnosis were not associated with overall survival in MM, except that a higher BMI at diagnosis was associated with a better overall survival for females, irrespective of race/ethnicity. This is the first evidence that the BMI-survival association may differ by sex. Obesity is associated with survival in several solid tumors and non-Hodgkin lymphoma, but its impact on multiple myeloma (MM) survival is unclear. We examined the associations between body mass index (BMI) at different periods of life up to the time of diagnosis and overall survival (OS) among 563 patients newly diagnosed with MM in 2010–2019. BMI at diagnosis was calculated using measured height and weight from electronic medical records (EMR). BMIs at age 20, maximum during adulthood, and 5 years before diagnosis were calculated using self-reported weights and measured height from EMR. Over a median follow-up of 49.3 months, 191 (33.93%) deaths were identified. We used multivariable Cox proportional-hazards models to examine the associations between BMIs and OS. Height as well as BMI before and at diagnosis was not associated with OS, but there is a U-shape association between weight and OS. Higher BMIs at diagnosis were associated with better OS among females (HR = 0.39 [0.22–0.71]), irrespective of race. In conclusion, our results suggest that BMI at different periods of life up to the time of diagnosis may not be associated with OS in MM, except that a higher BMI at diagnosis was associated with superior OS for females.
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影响因子：
2.6
作者：
Chihara D;Larson MC;Robinson DP;Thompson CA;Maurer MJ;Casulo C;Pophali P;Link BK;Habermann TM;Feldman AL;Flowers CR;Cerhan JR;Morton LM
通讯作者：
Morton LM
影响因子：
8.8
作者：
Anderson AS;Martin RM;Renehan AG;Cade J;Copson ER;Cross AJ;Grimmett C;Keaver L;King A;Riboli E;Shaw C;Saxton JM;UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
通讯作者：
UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
影响因子：
7.9
作者：
Karastergiou K;Smith SR;Greenberg AS;Fried SK
通讯作者：
Fried SK
影响因子：
12.8
作者：
Derman, Benjamin A.;Jasielec, Jagoda;Chiu, Brian C-H
通讯作者：
Chiu, Brian C-H
影响因子：
20.3
作者：
Fowler, Jessica A.;Lwin, Seint T.;Edwards, Claire M.
通讯作者：
Edwards, Claire M.