Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions
Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions
复制标题
恶性乳腺肿瘤的增殖和 DNA 倍性与早期口服避孕药使用和早期流产的关系
作者：
MD H. Olsson;MA J. Ranstam;PhD B. Baldetorp;MD S.;PhD M. Ferno;MD D. Killander;MD H. Sigurdsson
在175例绝经前乳腺癌患者中，20岁之前使用口服避孕药（OC）的患者与晚期或从未使用过口服避孕药的患者相比，具有较高的肿瘤细胞增殖活性，其S期分数（SPF）较高，DNA非整倍体肿瘤的比例较高（P = 0.05和P = 0.01）。在非整倍体肿瘤患者中，早期使用OC者的SPF值较高，而在整倍体肿瘤患者中则不明显。与其他年轻乳腺癌患者相比，首次足月妊娠前流产（自然流产或人工流产）的SPF值也较高（P = 0.03）。分别调整胎次和流产或口服避孕药的使用，早期口服避孕药与43%的SPF高相关，早期流产与49%的SPF高相关。年轻患者具有较高的SPF值和较高的非整倍体肿瘤频率，但发现这是因为使用OC的患者在诊断时的中位年龄较低。在从未使用过的人群中，SPF或非整倍体的频率没有明显的年龄关系。对于DNA分析，选择了肿瘤较大的乳腺癌患者，因此本文得出的结论可能不适用于较小的原发肿瘤患者，例如在乳腺癌筛查中诊断出的病例。与其他年轻女性乳腺癌患者相比，早期使用OC患者的预后指标和生存率较差，而早期使用OC患者的肿瘤增殖活性和非整倍体发生率较高，这与先前报道的结果一致。
In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S‐phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P = 0.05 and P = 0.01, respectively). The higher SPF among early OC users was apparent in patients with aneuploid tumors but not in patients with euploid tumors. Abortions (spontaneous or induced) before the first full‐term pregnancy also were associated with a higher SPF compared with other young patients with breast cancer (P = 0.03). Adjusting for parity and abortions or OC use, respectively, an early OC use was associated with a 43% higher SPF and early abortions were associated with 49% higher SPF. Younger patients had a higher SPF and a higher frequency of aneuploid tumors, but this was found to be because the users of OC had a lower median age at diagnosis. Among never users, no significant age relationship was seen for SPF or the frequency of aneuploidy. For the DNA analyses there is a selection of patients with breast cancer with larger tumors, and therefore the conclusions drawn in this article may not be generalizable to patients with smaller primary tumors, e.g., cases diagnosed at breast cancer screening. The higher tumor proliferative activity and frequency of aneuploidy in early OC users are in line with previously reported findings of worse prognostic indicators and a worse survival in early users of OC compared with other young women with breast cancer.
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影响因子：
8.8
作者：
Pike MC;Henderson BE;Casagrande JT;Rosario I;Gray GE
通讯作者：
Gray GE
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DOI：
--
发表时间：
1987
期刊：
Journal of the National Cancer Institute
影响因子：
--
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DOI：
10.1002/cyto.990010309
发表时间：
1980
期刊：
Cytometry
影响因子：
--
作者：
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通讯作者：
Temple,WJ
影响因子：
2.9
作者：
Stadel,BV;Lai,SH;Schlesselman,JJ;Murray,P
通讯作者：
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