Distributed sensory coding by cerebellar complex spikes in units of cortical segments.
Distributed sensory coding by cerebellar complex spikes in units of cortical segments.
复制标题
以皮质节段为单位的小脑复合体尖峰的分布式感觉编码。
DOI：
10.1016/j.celrep.2021.109966
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发表时间：
2021
期刊：
影响因子：
8.8
通讯作者：
A Miyawaki
中科院分区：
文献类型：
--
作者：
A Michikawa;T Yoshida;S Kuroki;T Ishikawa;SKakei;R Kimizuka;A Saito;H Yokota;A Shimizu;S Itohara;A Miyawaki
感觉处理对于运动控制是必不可少的。来自下橄榄的攀爬纤维将感觉信号传递给浦肯野细胞，但这些信号如何在小脑皮层中表现出来仍然是一个谜。为了检查小鼠大脑的左小脑组织，我们进行了定量Ca2+成像，以测量同时在整个小脑背表面爬升纤维输入引起的复杂尖峰（CSs）。表面被分成大约200个片段，每个片段由约100个浦肯野细胞组成，这些细胞同步发射CSs。Ourin体内成像显示，尽管单独刺激四肢肌肉会在几乎所有节段中引发相似的全局CS反应，但刺激的时间和位置是通过贝叶斯推断得出的，该推断是在单个试验基础上通过多个节段的协调激活和失活得出的。我们提出，小脑执行基于片段的分布式种群编码，表示感觉事件的条件概率。
Sensory processing is essential for motor control. Climbing fibers from the inferior olive transmit sensory signals to Purkinje cells, but how the signals are represented in the cerebellar cortex remains elusive. To examine the olivocerebellar organization of the mouse brain, we perform quantitative Ca2+imaging to measure complex spikes (CSs) evoked by climbing fiber inputs over the entire dorsal surface of the cerebellum simultaneously. The surface is divided into approximately 200 segments, each composed of ∼100 Purkinje cells that fire CSs synchronously. Ourin vivoimaging reveals that, although stimulation of four limb muscles individually elicits similar global CS responses across nearly all segments, the timing and location of a stimulus are derived by Bayesian inference from coordinated activation and inactivation of multiple segments on a single trial basis. We propose that the cerebellum performs segment-based, distributed-population coding that represents the conditional probability of sensory events.
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影响因子：
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