Transformation of Cortex-wide Emergent Properties during Motor Learning.
Transformation of Cortex-wide Emergent Properties during Motor Learning.
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DOI：
10.1016/j.neuron.2017.04.015
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发表时间：
2017-05-17
期刊：
影响因子：
16.2
通讯作者：
Komiyama T
中科院分区：
文献类型：
--
作者：
Makino H;Ren C;Liu H;Kim AN;Kondapaneni N;Liu X;Kuzum D;Komiyama T
学习涉及全脑运作动力学的转变。然而，我们对宏观动态中与学习相关的变化的理解是有限的。在这里，我们使用宽场钙成像技术监测了小鼠大脑皮层的活动，同时小鼠在几周内学习了运动任务。在学习过程中，皮层模块之间的顺序活动在时间上变得更加压缩，其逐个试验的变异性降低。此外，在学习过程中出现了一个新的活动流，起源于运动前皮层（M2），M2成为许多其他模块活动的预测。失活实验表明，M2是关键的学习后动力学在整个皮层活动。此外，双光子钙成像显示，M2整体活动也显示出更早的活动开始和减少的变异性与学习，这是伴随着活动-运动关系的变化。这些结果揭示了运动学习过程中新出现的宏观皮层动力学特性，并突出了M2在控制学习运动中的重要性。
Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements.
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