Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1h nmr spectroscopic imaging
Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1h nmr spectroscopic imaging
复制标题
1h核磁共振波谱成像检测人颅内肿瘤体内代谢异质性
DOI：
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发表时间：
1990
影响因子：
3.3
通讯作者：
J. D. den Hollander
中科院分区：
文献类型：
--
作者：
C. Segebarth;D. Baleriaux;P. Luyten;J. D. den Hollander
通过局部水抑制1H NMR单体积光谱和光谱成像检查颅内肿瘤（神经胶质瘤）患者。肿瘤的1H NMR光谱显示N-乙酰天冬氨酸、胆碱化合物和肌酸加磷酸肌酸共振线的信号强度与正常脑组织中观察到的相应强度不同。此外，对于到目前为止检查的10名患者中的6名，在肿瘤光谱中检测到乳酸共振线。对于一个病人，异常的1H NMR光谱，获得了一个半球，似乎正常的1H NMR成像。肿瘤区域的代谢异质性可以用1H NMR光谱成像来证明，使用1 cm量级的空间分辨率。这些结果表明，代谢观察的频谱，最终可能提供一个重要的手段，为脑肿瘤的特征。
Patients with intracranial tumors (gliomas) were examined by means of localized water‐suppressed 1H NMR single volume spectroscopy and spectroscopic imaging. The 1H NMR spectra of the tumors exhibit signal intensities of the N‐acetyl aspartate, choline compounds, and creatine plus phosphocreatine resonance lines that are different from the corresponding intensities observed on normal brain tissue. Also, for 6 out of the 10 patients examined so far, lactate resonance lines were detected in the tumor spectra. For one patient, abnormal 1H NMR spectra were obtained of a hemisphere which appeared normal with 1H NMR imaging. Metabolic heterogeneity of the tumorous regions could be demonstrated with 1H NMR spectroscopic imaging, using a spatial resolution in the order of 1 cm. These results suggest a spectrum of metabolic observations that may ultimately provide an important means for characterizing brain tumors.
DOI：
10.1073/pnas.80.16.4945
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BEHAR, KL;DENHOLLANDER, JA;PRICHARD, JW
通讯作者：
PRICHARD, JW
人神经母细胞瘤原位 31P 核磁共振波谱研究。
DOI：
10.1056/nejm198506063122307
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Maris,JM;Evans,AE;McLaughlin,AC;D'Angio,GJ;Bolinger,L;Manos,H;Chance,B
通讯作者：
Chance,B
DOI：
10.1073/pnas.81.20.6330
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ROTHMAN, DL;BEHAR, KL;SHULMAN, RG
通讯作者：
SHULMAN, RG