Expression of vitamin D receptor decreases during progression of pigmented skin lesions.
Expression of vitamin D receptor decreases during progression of pigmented skin lesions.
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DOI：
10.1016/j.humpath.2010.09.014
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发表时间：
2011-05
期刊：
影响因子：
3.3
通讯作者：
Slominski, Andrzej T.
中科院分区：
文献类型：
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作者：
Brozyna, Anna A.;Jozwicki, Wojciech;Janjetovic, Zorica;Slominski, Andrzej T.
1,25-dihydroxyvitamin D3 affects proliferation, differentiation and apoptosis and protects DNA against oxidative damage with a net tumorostatic and anticancerogenic effects. It acts through a specific nuclear receptor that is widely distributed through the body. Although a beneficial role of vitamin D in melanoma patients has been suggested, there is a lack of information on the changes in the expression pattern of vitamin D receptor during progression of pigmented lesions. Using immunohistochemistry, we analyzed expression of vitamin D receptor in 140 samples obtained form 82 patients, including 25 benign nevi, 70 primary cutaneous melanomas, 35 metastases, 5 re-excisions, and 5 normal skin biopsies. The strongest expression was observed in normal skin that significantly decreased in melanocytic proliferations with the following order of expression: normal skin > melanocytic nevi > melanomas = metastases. The vitamin D receptor expression in skin surrounding nevi and melanoma was also significantly reduced as compared to normal skin. Tumor-infiltrating and lymph node lymphocytes retained high levels of vitamin D receptor. There was negative correlation between tumor progression and vitamin D receptor expression with a remarkable decrease of the immunoreactivity in nuclei of melanoma cells at vertical versus radial growth phases, and with metastatic melanomas showing the lowest cytoplasmic receptor staining. Furthermore, lack of the receptor expression in primary melanomas and metastases was related to shorter overall patients’ survival. In addition, the receptor expression decreased in melanized melanoma cells in comparison to amelanotic or poorly pigmented cells. Therefore, we propose that reduction or absence of vitamin D receptor is linked to progression of melanocytic lesions, that its lack affects survival of melanoma patients, and that melanogenesis can attenuate the receptor expression. In conclusion, changes in vitamin D receptor expression pattern can serve as important variables for diagnosis, predicting clinical outcome of the disease and/or as a guidance for novel therapy of melanomas based on use of vitamin D or its derivatives.
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DOI：
10.1093/jnci/dji019
发表时间：
2005-02-02
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Berwick, M;Armstrong, BK;Barnhill, R
通讯作者：
Barnhill, R
影响因子：
6.2
作者：
Mocellin, Simone;Nitti, Donato
通讯作者：
Nitti, Donato
影响因子：
5
作者：
Mitschele, T;Diesel, B;Reichrath, J
通讯作者：
Reichrath, J
影响因子：
8.4
作者：
Randerson-Moor, Juliette A.;Taylor, John C.;Elliott, Faye;Chang, Yu-Mei;Beswick, Samantha;Kukalizch, Kairen;Affleck, Paul;Leake, Susan;Haynes, Sue;Karpavicius, Birute;Marsden, Jerry;Gerry, Edwina;Bale, Linda;Bertram, Chandra;Field, Helen;Barth, Julian H.;Silva, Isabel dos Santos;Swerdlow, Anthony;Kanetsky, Peter A.;Barrett, Jennifer H.;Bishop, D. Timothy;Bishop, Julia A. Newton
通讯作者：
Bishop, Julia A. Newton
影响因子：
8.8
作者：
通讯作者：
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