Dairy product consumption and risk of hip fracture: a systematic review and meta-analysis.
Dairy product consumption and risk of hip fracture: a systematic review and meta-analysis.
复制标题
乳制品消费和髋部骨折的风险：系统评价和荟萃分析。
DOI：
10.1186/s12889-018-5041-5
复制
发表时间：
2018-01-22
影响因子：
4.5
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Bian S;Hu J;Zhang K;Wang Y;Yu M;Ma J
乳制品消费可能会影响髋部骨折的风险，但之前的研究报告的结果不一致。我们荟萃分析的主要目的是检查和量化乳制品消费与髋部骨折风险的潜在关联。我们检索了PubMed和EMBASE的数据库，从它们成立到2017年4月17日的相关文章。最终分析包括10项队列研究和8项病例对照研究。随机效应模型用于估计合并风险。我们进行了亚组和剂量反应分析，以探讨牛奶摄入量与髋部骨折风险之间的关系。在汇总纳入研究的数据后，最高和最低消费的髋部骨折的总相对危险度（RR）分别为0.91 （95% CI: 0.74-1.12）、0.75 （95% CI: 0.66-0.86）和0.68 （95% CI: 0.61-0）。在队列研究中，牛奶、酸奶、奶酪和所有乳制品的风险分别为1.02 （95% CI: 0.93-1.12）。更高的牛奶消费量[优势比（OR）， 0.71, 95% CI: 0.55-0]。[91]在病例对照研究中，高摄入量与低摄入量与髋部骨折风险较低相关。在量化牛奶的特定剂量后，200克/天牛奶摄入量增加的总RR/OR分别为1.00 （95%CI: 0.94-1.07）和0.89 (95%CI: 0.64-1.24)，在队列研究和病例对照研究中具有显著的异质性；在队列研究和病例对照研究中，牛奶摄入量与髋部骨折风险之间存在非线性关联。我们的研究结果表明，在队列研究中，酸奶和奶酪的消费与髋部骨折的风险较低有关。然而，乳制品和奶油的总消费量与髋部骨折的风险没有显著关联。没有足够的证据来推断牛奶摄入量和髋部骨折风险之间的联系。每天200克牛奶摄入量的较低阈值可能有有益的影响，而较高阈值的牛奶摄入量的影响尚不清楚。本文的在线版本（10.1186/s12889-018-5041-5）包含补充资料，仅供授权用户使用。
Dairy product consumption may affect the risk of hip fracture, but previous studies have reported inconsistent findings. The primary aim of our meta-analysis was to examine and quantify the potential association of dairy product consumption with risk of hip fracture. We searched the databases of PubMed and EMBASE for relevant articles from their inception through April 17, 2017. The final analysis included 10 cohort studies and 8 case-control studies. Random-effects models were used to estimate the pooled risk. Subgroup and dose-response analyses were conducted to explore the relationships between the consumption of milk and the risk of hip fracture. After pooling the data from the included studies, the summary relative risk (RR) for hip fracture for highest versus lowest consumption were 0.91 (95% CI: 0.74–1.12), 0.75 (95% CI: 0.66–0.86), 0.68 (95% CI: 0.61–0. 77), 1.02 (95% CI: 0.93–1.12) for milk, yogurt, cheese, and total dairy products in cohort studies, respectively. Higher milk consumption [Odds ratio (OR), 0.71, 95% CI: 0.55–0. 91] was associated with lower risk of hip fracture for highest versus lowest consumption in case-control studies. After quantifying the specific dose of milk, the summary RR/OR for an increased milk consumption of 200 g/day was 1.00 (95% CI: 0.94–1.07), and 0.89 (95%CI: 0.64–1.24) with significant heterogeneity for cohort and case-control studies, respectively; There was a nonlinear association between milk consumption and hip fracture risk in cohort, and case-control studies. Our findings indicate that consumption of yogurt and cheese was associated with lower risk of hip fracture in cohort studies. However, the consumption of total dairy products and cream was not significantly associated with the risk of hip fracture. There was insufficient evidence to deduce the association between milk consumption and risk of hip fracture. A lower threshold of 200 g/day milk intake may have beneficial effects, whereas the effects of a higher threshold of milk intake are unclear. The online version of this article (10.1186/s12889-018-5041-5) contains supplementary material, which is available to authorized users.
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
4
作者：
De Laet, C;Kanis, JA;Tenenhouse, A
通讯作者：
Tenenhouse, A
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4
作者：
COOPER, C;CAMPION, G;MELTON, LJ
通讯作者：
MELTON, LJ