Novelty Detection in the Human Auditory Brainstem
Novelty Detection in the Human Auditory Brainstem
复制标题
人类听觉脑干的新颖性检测
作者：
L. Slabu;Sabine Grimm;C. Escera
听觉异常检测与人类听觉诱发电位(AEP)有关，AEP是在声音变化开始时在听觉皮质产生的失配负波。然而，动物的单单位记录显示出更早的(∼20-40毫秒)，以及解剖学上更低的(即丘脑和中脑)异常检测。在人类中，头皮中潜伏期AEP的记录已经证实了早期(∼30-40毫秒)的异常检测。然而，人类听觉脑干参与异常检测的研究尚未得到证实。在这里，我们记录了年轻人对辅音-元音刺激(/ba/，/wa/)的听性脑干频率跟随反应(FFR)，刺激以奇怪和反转的奇怪块排列(偏离概率，p=0.2)，允许比较相同物理刺激在不同上下文角色中的FFR。虽然没有观察到/wa/音节的影响，但我们发现/ba/音节的脑干FFR减少到与标准刺激和控制区块中排列的类似刺激相比的偏离刺激，其中有五个相同概率的很少出现的声音。这些发现表明，人类听觉脑干能够编码最近听觉过去的规律性，以检测新的事件，并证实人类异常检测的多个解剖和时间尺度。
Auditory deviance detection has been associated with a human auditory-evoked potential (AEP), the mismatch negativity, generated in the auditory cortex 100–200 ms from sound change onset. Yet, single-unit recordings in animals suggest much earlier (∼20–40 ms), and anatomically lower (i.e., thalamus and midbrain) deviance detection. In humans, recordings of the scalp middle-latency AEPs have confirmed early (∼30–40 ms) deviance detection. However, involvement of the human auditory brainstem in deviance detection has not yet been demonstrated. Here we recorded the auditory brainstem frequency-following response (FFR) to consonant-vowel stimuli (/ba/, /wa/) in young adults, with stimuli arranged in oddball and reversed oddball blocks (deviant probability, p = 0.2), allowing for the comparison of FFRs to the same physical stimuli presented in different contextual roles. Whereas no effect was observed for the /wa/ syllable, we found for the /ba/ syllable a reduction in the brainstem FFR to deviant stimuli compared with standard ones and to similar stimuli arranged in a control block, with five equiprobable, rarely occurring sounds. These findings demonstrate that the human auditory brainstem is able to encode regularities in the recent auditory past to detect novel events, and confirm the multiple anatomical and temporal scales of human deviance detection.
影响因子：
3.7
作者：
Banai, Karen;Hornickel, Jane;Kraus, Nina
通讯作者：
Kraus, Nina
影响因子：
3.7
作者：
Chandrasekaran B;Kraus N
通讯作者：
Kraus N
DOI：
10.1016/0168-5597(94)90100-7
发表时间：
1994-07-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
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作者：
GALBRAITH, GC
通讯作者：
GALBRAITH, GC