Recent Progress in Cardiovascular Research Involving Single-Cell Omics Approaches.
Recent Progress in Cardiovascular Research Involving Single-Cell Omics Approaches.
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DOI：
10.3389/fcvm.2021.783398
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发表时间：
2021
影响因子：
3.6
通讯作者：
Nomura S
中科院分区：
文献类型：
--
作者：
Dai Z;Nomura S
心血管疾病是全世界发病率和死亡率的主要原因之一。虽然心脏从发育到疾病的谱系已经研究了很长时间，但它在很大程度上仍然是个谜。单细胞组学技术的出现为定义细胞异质性、解开以前未知的通路和揭示细胞间通讯提供了强大的工具箱，从而促进了生物医学研究，并在过去7年中获得了许多新的发现。没有单细胞组学技术，不仅正常和发育中心脏的细胞图谱提供了大量的研究资源，而且一些关于细胞类型特异性疾病基因程序的重要发现也不可能建立。在此，我们简要介绍了单细胞组学的最新技术进展，并总结了这些方法取得的主要成果，重点是心脏的发育和稳态，心肌梗死和心力衰竭。
Cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Although the spectrum of the heart from development to disease has long been studied, it remains largely enigmatic. The emergence of single-cell omics technologies has provided a powerful toolbox for defining cell heterogeneity, unraveling previously unknown pathways, and revealing intercellular communications, thereby boosting biomedical research and obtaining numerous novel findings over the last 7 years. Not only cell atlases of normal and developing hearts that provided substantial research resources, but also some important findings regarding cell-type-specific disease gene program, could never have been established without single-cell omics technologies. Herein, we briefly describe the latest technological advances in single-cell omics and summarize the major findings achieved by such approaches, with a focus on development and homeostasis of the heart, myocardial infarction, and heart failure.
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影响因子：
16.6
作者：
Jia G;Preussner J;Chen X;Guenther S;Yuan X;Yekelchyk M;Kuenne C;Looso M;Zhou Y;Teichmann S;Braun T
通讯作者：
Braun T
IRF3和I型干扰物为心肌梗死提供了致命的反应。
影响因子：
82.9
作者：
King KR;Aguirre AD;Ye YX;Sun Y;Roh JD;Ng RP Jr;Kohler RH;Arlauckas SP;Iwamoto Y;Savol A;Sadreyev RI;Kelly M;Fitzgibbons TP;Fitzgerald KA;Mitchison T;Libby P;Nahrendorf M;Weissleder R
通讯作者：
Weissleder R
影响因子：
11.8
作者：
DeLaughter, Daniel M.;Bick, Alexander G.;Wakimoto, Hiroko;McKean, David;Gorham, Joshua M.;Kathiriya, Irian S.;Hinson, John T.;Homsy, Jason;Gray, Jesse;Pu, William;Bruneau, Benoit G.;Seidman, J. G.;Seidman, Christine E.
通讯作者：
Seidman, Christine E.
影响因子：
64.8
作者：
Delorey TM;Ziegler CGK;Heimberg G;Normand R;Yang Y;Segerstolpe Å;Abbondanza D;Fleming SJ;Subramanian A;Montoro DT;Jagadeesh KA;Dey KK;Sen P;Slyper M;Pita-Juárez YH;Phillips D;Biermann J;Bloom-Ackermann Z;Barkas N;Ganna A;Gomez J;Melms JC;Katsyv I;Normandin E;Naderi P;Popov YV;Raju SS;Niezen S;Tsai LT;Siddle KJ;Sud M;Tran VM;Vellarikkal SK;Wang Y;Amir-Zilberstein L;Atri DS;Beechem J;Brook OR;Chen J;Divakar P;Dorceus P;Engreitz JM;Essene A;Fitzgerald DM;Fropf R;Gazal S;Gould J;Grzyb J;Harvey T;Hecht J;Hether T;Jané-Valbuena J;Leney-Greene M;Ma H;McCabe C;McLoughlin DE;Miller EM;Muus C;Niemi M;Padera R;Pan L;Pant D;Pe'er C;Pfiffner-Borges J;Pinto CJ;Plaisted J;Reeves J;Ross M;Rudy M;Rueckert EH;Siciliano M;Sturm A;Todres E;Waghray A;Warren S;Zhang S;Zollinger DR;Cosimi L;Gupta RM;Hacohen N;Hibshoosh H;Hide W;Price AL;Rajagopal J;Tata PR;Riedel S;Szabo G;Tickle TL;Ellinor PT;Hung D;Sabeti PC;Novak R;Rogers R;Ingber DE;Jiang ZG;Juric D;Babadi M;Farhi SL;Izar B;Stone JR;Vlachos IS;Solomon IH;Ashenberg O;Porter CBM;Li B;Shalek AK;Villani AC;Rozenblatt-Rosen O;Regev A
通讯作者：
Regev A
影响因子：
64.5
作者：
Asp, Michaela;Giacomello, Stefania;Lundeberg, Joakim
通讯作者：
Lundeberg, Joakim