Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain.
Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain.
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DOI：
10.1073/pnas.2010817117
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发表时间：
2020-10-06
影响因子：
11.1
通讯作者：
Vergara-Alert J
中科院分区：
文献类型：
--
作者：
Segalés J;Puig M;Rodon J;Avila-Nieto C;Carrillo J;Cantero G;Terrón MT;Cruz S;Parera M;Noguera-Julián M;Izquierdo-Useros N;Guallar V;Vidal E;Valencia A;Blanco I;Blanco J;Clotet B;Vergara-Alert J
COVID-19是近代史上最具破坏性的大流行病。与许多新出现的传染病一样，它是人畜共患疾病，这意味着动物在最初的传播事件中发挥了主要作用。尽管SARS-CoV-2高度适应于在人与人之间传播，但一些动物物种自然易感染SARS-CoV-2，包括猫等宠物。在本报告中，来自一个家庭的一只猫有几个亲戚受到COVID-19的影响，出现了严重的呼吸道临床症状，导致人道主义安乐死。由于怀疑猫可能感染COVID-19，因此进行了不同的死前和死后检测。临床状况最终归因于猫肥厚型心肌病，但动物也感染了SARS-CoV-2。严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）是COVID-19的病原体，是一种主要通过人传人的人畜共患病原体。很少有报告表明宠物可能接触到病毒。本报告描述了一只患有严重呼吸窘迫和血小板减少症的猫，该猫与一个有多名成员受COVID-19影响的家庭生活在一起。这只猫的临床症状促使人道主义安乐死和详细的尸检调查，以评估是否是COVID-19样疾病导致了这种情况。尸检结果显示该动物患有猫肥厚性心肌病和严重的肺水肿和血栓形成。仅在鼻拭子、鼻甲和肠系膜淋巴结中检测到SARS-CoV-2 RNA，但未检测到与病毒感染相符的组织病理学病变证据。这只猫对SARS-CoV-2进行了血清转化，进一步证明了这只动物的生产性感染。我们得出结论，该动物患有亚临床SARS-CoV-2感染，伴随着导致安乐死的不相关心肌病。
COVID-19 is the most devastating pandemic in recent history. As with many emerging infectious diseases, it is of zoonotic origin, meaning that animals played a major role in the initial transmission events. Despite SARS-CoV-2 being highly adapted to jump from human to human, several animal species are naturally susceptible to SARS-CoV-2, including pets such as cats. In the present report, a cat from a family with several relatives affected by COVID-19 developed severe respiratory clinical signs, leading to humanitarian euthanasia. Due to the suspicion of a potential COVID-19 infection in the cat, different antemortem and postmortem tests were assayed. The clinical condition was finally attributed to a feline hypertrophic cardiomyopathy, but the animal was also infected by SARS-CoV-2. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may be exposed to the virus. The present report describes a cat suffering from severe respiratory distress and thrombocytopenia living with a family with several members affected by COVID-19. Clinical signs of the cat prompted humanitarian euthanasia and a detailed postmortem investigation to assess whether a COVID-19−like disease was causing the condition. Necropsy results showed the animal suffered from feline hypertrophic cardiomyopathy and severe pulmonary edema and thrombosis. SARS-CoV-2 RNA was only detected in nasal swab, nasal turbinates, and mesenteric lymph node, but no evidence of histopathological lesions compatible with a viral infection were detected. The cat seroconverted against SARS-CoV-2, further evidencing a productive infection in this animal. We conclude that the animal had a subclinical SARS-CoV-2 infection concomitant to an unrelated cardiomyopathy that led to euthanasia.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
DOI：
10.1093/bioinformatics/btt593
发表时间：
2014-03-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Zhang J;Kobert K;Flouri T;Stamatakis A
通讯作者：
Stamatakis A
影响因子：
30.3
作者：
Kim, Young-Il;Kim, Seong-Gyu;Choi, Young Ki
通讯作者：
Choi, Young Ki
影响因子：
56.9
作者：
Rockx, Barry;Kuiken, Thijs;Haagmans, Bart L.
通讯作者：
Haagmans, Bart L.
影响因子：
3.7
作者：
Yu, Pin;Qi, Feifei;Qin, Chuan
通讯作者：
Qin, Chuan