Differences in the functional responses of two cell lines each expressing Pi-hydrolysis-coupled muscarinic receptors.
Differences in the functional responses of two cell lines each expressing Pi-hydrolysis-coupled muscarinic receptors.
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分别表达 Pi 水解偶联毒蕈碱受体的两种细胞系的功能反应差异。
DOI：
10.1007/bf00974580
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发表时间：
1992
影响因子：
4.4
通讯作者：
Paek,R
中科院分区：
文献类型：
--
作者：
Baumgold,J;Paek,R
Fluorescent oxonol dyes were used to measure changes in the membrane potential of two different cell lines each expressing Pi-hydrolysis coupled muscarinic receptors. Both SK-N-SH human neuroblastoma cells and m1-transfected A9 L cells express muscarinic receptors, which, when stimulated, elicit a large increase in intracellular calcium, and release of inositol phosphates. Despite the similarity in this second-messenger response, muscarinic stimulation resulted in a hyperpolarization in the transfected A9 L cells whereas a small depolarization was observed in the neuroblastoma cells. The carbachol-mediated hyperpolarization of the transfected A9 L cells could be mimicked by increasing intracellular calcium with the ionophore A23187, suggesting, that it may be mediated by calcium-activated potassium channels. Exposure of SK-N-SH cells to A23187, on the other hand, had no effect on the membrane potential. These studies demonstrate that the activation of a second messenger system does not solely dictate the electrophysiological response of a cell, but that other factors such as the expression of ion-channels is critical in the determination of that response.
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