The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects.
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects.
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DOI：
10.1038/s41420-023-01666-w
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发表时间：
2023-09-29
影响因子：
7
通讯作者：
Yu, Qin
中科院分区：
文献类型：
--
作者：
Li, Congxin;Peng, Kaixin;Xiao, Siqi;Long, Yuanyuan;Yu, Qin
炎症性肠病（IBD）是一种慢性非特异性肠道炎症性疾病，包括溃疡性结肠炎（UC）和克罗恩病（CD）。IBD与全身炎症反应密切相关，并影响许多肠道和肠外疾病的进展。作为IBD益生菌辅助治疗的代表性细菌之一，多株乳杆菌已被证明可以减轻肠道损伤，增强肠道免疫屏障、上皮细胞屏障和粘液屏障。乳杆菌还不遗余力地通过肠-脑轴和肠-肝轴缓解炎症性肠病相关疾病，如结肠炎相关的结直肠癌（CAC）、阿尔茨海默病（AD）、抑郁症、焦虑症、自身免疫性肝炎（AIH）等。本文旨在讨论乳酸杆菌在IBD及IBD相关疾病中的作用，包括其潜在机制和相关的治疗策略。
Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn’s Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many intestinal and extraintestinal diseases. As one of the representative bacteria for probiotic-assisted therapy in IBD, multiple strains of Lactobacillus have been proven to alleviate intestinal damage and strengthen the intestinal immunological barrier, epithelial cell barrier, and mucus barrier. Lactobacillus also spares no effort in the alleviation of IBD-related diseases such as Colitis-associated Colorectal cancer (CAC), Alzheimer’s Disease (AD), Depression, Anxiety, Autoimmune Hepatitis (AIH), and so on via gut-brain axis and gut-liver axis. This article aims to discuss the role of Lactobacillus in IBD and IBD-related diseases, including its underlying mechanisms and related curative strategies from the present to the future.
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