Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk.
Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk.
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DOI：
10.1371/journal.pone.0240437
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Suh JH
中科院分区：
文献类型：
--
作者：
Mietus-Snyder M;Narayanan N;Krauss RM;Laine-Graves K;McCann JC;Shigenaga MK;McHugh TH;Ames BN;Suh JH
不良的饮食有助于肥胖、胰岛素抵抗和血脂异常的代谢并发症。代谢组学生物标志物可以作为早期营养敏感的健康指标。这项以家庭为基础的生活方式改变计划比较了干预组（INT）和对照组（CONT）的代谢结果，干预组（INT）每天食用2根营养棒，持续2个月。超重，主要是少数民族和女性青少年（青少年）/家长成人照顾（PAC）的家庭单位招募从儿科肥胖症诊所。CONT（8名青少年，8名PAC）和INT（10名青少年，10名PAC）组随机接受营养棒补充，每周参加一次课程，包括团体营养咨询和监督锻炼。测量治疗前后的身体和行为参数、空腹传统生物标志物、血浆鞘脂和氨基酸代谢产物。在整个队列中，基线鞘脂神经酰胺主成分复合评分与脂联素、甘油三酯、富含甘油三酯的极低密度脂蛋白和致动脉粥样硬化小低密度脂蛋白（LDL）亚类相关。鞘磷脂综合评分与C反应蛋白、二氢神经酰胺综合评分与舒张压、谷胱甘肽与空腹胰岛素和胰岛素抵抗稳态模型的最终主成分之间呈负相关。在CONT中，血浆神经酰胺、二氢鞘氨醇、鞘氨醇和氨基酸代谢产物增加，可能是由于体力活动增加。营养棒补充剂（INT）减弱了这种上升，并显着降低了尿素，芳香族和产气氨基酸代谢产物。代谢组学变化与血脂异常临床生物标志物的改善呈正相关。在肥胖青少年和PAC中增加体力活动的营养棒补充剂可促进与改善血脂异常相关的有利代谢组学变化。本文报道的分析所来自的试验是在clinicaltrials.gov注册为NCT 02239198的一系列营养棒临床试验的一部分。
Poor diets contribute to metabolic complications of obesity, insulin resistance and dyslipidemia. Metabolomic biomarkers may serve as early nutrition-sensitive health indicators. This family-based lifestyle change program compared metabolic outcomes in an intervention group (INT) that consumed 2 nutrient bars daily for 2-months and a control group (CONT). Overweight, predominantly minority and female adolescent (Teen)/parent adult caretaker (PAC) family units were recruited from a pediatric obesity clinic. CONT (8 Teen, 8 PAC) and INT (10 Teen, 10 PAC) groups randomized to nutrient bar supplementation attended weekly classes that included group nutrition counseling and supervised exercise. Pre-post physical and behavioral parameters, fasting traditional biomarkers, plasma sphingolipids and amino acid metabolites were measured. In the full cohort, a baseline sphingolipid ceramide principal component composite score correlated with adiponectin, triglycerides, triglyceride-rich very low density lipoproteins, and atherogenic small low density lipoprotein (LDL) sublasses. Inverse associations were seen between a sphingomyelin composite score and C-reactive protein, a dihydroceramide composite score and diastolic blood pressure, and the final principal component that included glutathionone with fasting insulin and the homeostatic model of insulin resistance. In CONT, plasma ceramides, sphinganine, sphingosine and amino acid metabolites increased, presumably due to increased physical activity. Nutrient bar supplementation (INT) blunted this rise and significantly decreased ureagenic, aromatic and gluconeogenic amino acid metabolites. Metabolomic changes were positively correlated with improvements in clinical biomarkers of dyslipidemia. Nutrient bar supplementation with increased physical activity in obese Teens and PAC elicits favorable metabolomic changes that correlate with improved dyslipidemia. The trial from which the analyses reported upon herein was part of a series of nutrient bar clinical trials registered at clinicaltrials.gov as NCT02239198.
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影响因子：
3.1
作者：
Block, Gladys;Jensen, Christopher D.;Fung, Ellen B.
通讯作者：
Fung, Ellen B.
影响因子：
4.9
作者：
Gruber, H-J;Mayer, C.;Wilders-Truschnig, M.
通讯作者：
Wilders-Truschnig, M.
胰岛素敏化剂治疗对氨基酸及其代谢产物的影响。
DOI：
10.1016/j.metabol.2015.01.008
发表时间：
2015-06
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Irving BA;Carter RE;Soop M;Weymiller A;Syed H;Karakelides H;Bhagra S;Short KR;Tatpati L;Barazzoni R;Nair KS
通讯作者：
Nair KS
影响因子：
3.5
作者：
Cicero, Arrigo F. G.;Fogacci, Federica;Borghi, Claudio
通讯作者：
Borghi, Claudio
影响因子：
3.6
作者：
Altorf-van der Kuil, Wieke;Brink, Elizabeth J.;Geleijnse, Johanna M.
通讯作者：
Geleijnse, Johanna M.