Extended arrays for nonlinear susceptibility magnitude imaging.
Extended arrays for nonlinear susceptibility magnitude imaging.
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DOI：
10.1515/bmt-2015-0048
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Diamond SG
中科院分区：
文献类型：
--
作者：
Ficko BW;Giacometti P;Diamond SG
本研究利用多频互调和相位编码实现非线性磁化率成像（SMI）。成像网格由直径3.5 mm、高4.2 mm的六边形二维61体素网格构成，网格间距为5mm。样品孔中填充40 μl体积的Fe3O4淀粉包被磁性纳米颗粒（mNPs），其水动力直径为100 nm，浓度为25 mg/ml。成像硬件配置了三个激励线圈和三个检测线圈，预计更大的成像系统将具有激励和检测线圈阵列。mNP的六角形和条形在几个方向上成功成像（R2 > 0.9）。该SMI演示扩展了我们之前的工作，具有更大的线圈阵列、更大的视场、有效的相位编码方案、更小的mNP样本量和更复杂的成像模式，以测试将该方法扩展到中试规模之外的可行性。本研究的结果表明，非线性SMI有望进一步发展成为医疗应用的实用成像系统。
This study implements nonlinear susceptibility magnitude imaging (SMI) with multifrequency intermodulation and phase encoding. An imaging grid was constructed of cylindrical wells of 3.5-mm diameter and 4.2-mm height on a hexagonal two-dimensional 61-voxel pattern with 5-mm spacing. Patterns of sample wells were filled with 40-μl volumes of Fe3O4 starch-coated magnetic nanoparticles (mNPs) with a hydrodynamic diameter of 100 nm and a concentration of 25 mg/ml. The imaging hardware was configured with three excitation coils and three detection coils in anticipation that a larger imaging system will have arrays of excitation and detection coils. Hexagonal and bar patterns of mNP were successfully imaged (R2 > 0.9) at several orientations. This SMI demonstration extends our prior work to feature a larger coil array, enlarged field-of-view, effective phase encoding scheme, reduced mNP sample size, and more complex imaging patterns to test the feasibility of extending the method beyond the pilot scale. The results presented in this study show that nonlinear SMI holds promise for further development into a practical imaging system for medical applications.
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影响因子：
2.7
作者：
Ficko BW;Giacometti P;Diamond SG
通讯作者：
Diamond SG
影响因子：
3.5
作者：
Weizenecker, J.;Gleich, B.;Borgert, J.
通讯作者：
Borgert, J.
影响因子：
3.4
作者：
Sattel, Timo F.;Knopp, Tobias;Buzug, Thorsten M.
通讯作者：
Buzug, Thorsten M.
影响因子：
2.1
作者：
Nakamura, Kosuke;Ueda, Koji;Takemura, Yasushi
通讯作者：
Takemura, Yasushi
影响因子：
64.8
作者：
Gleich, B;Weizenecker, R
通讯作者：
Weizenecker, R