Circulation and transmission of clones of Vibrio cholerae during cholera outbreaks.
Circulation and transmission of clones of Vibrio cholerae during cholera outbreaks.
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DOI：
10.1007/82_2013_360
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发表时间：
2014
影响因子：
--
通讯作者：
Morris, J. Glenn, Jr.
中科院分区：
文献类型：
--
作者：
Stine, O. Colin;Morris, J. Glenn, Jr.
霍乱仍然是一个重大的公共卫生问题。潜在的细菌病原体霍乱弧菌（V. cholesterol）正在进化，它的一些突变已经为爆发奠定了基础。在霍乱弧菌获得了VSP I和VSP II的移动的元素后，埃尔托大流行开始并蔓延到整个热带地区。O 1血清型编码基因被O 139编码基因取代，引发了席卷印度次大陆的疫情。sxt元件产生了第三次选择性扫描，最近的第四次扫描与El Tor背景中El Tor ctx等位基因与经典ctx等位基因的交换相关。在肯尼亚，这第四次选择性扫描的变种已经分化，并成为当地的居住和出现环境水库。在地方一级，孟加拉国的研究表明，疫情可能是由环境中遗传谱系的一个非随机子集引起的，随着病原体数量的扩大，可能会发现许多新的突变，从而增加遗传变异的数量，这种现象被称为创始人冲水。在海地，霍乱弧菌在2010年首次入侵和扩张后，在特定突变的自然选择的驱动下，于2011-2012年冬季发生了第二次疫情。
Cholera is still a major public health problem. The underlying bacterial pathogen Vibrio cholerae (V. cholerae) is evolving and some of its mutations have set the stage for outbreaks. After V. cholerae acquired the mobile elements VSP I & II, the El Tor pandemic began and spread across the tropics. The replacement of the O1 serotype encoding genes with the O139 encoding genes triggered an outbreak that swept across the Indian subcontinent. The sxt element generated a third selective sweep and most recently a fourth sweep was associated with the exchange of the El Tor ctx allele for a classical ctx allele in the El Tor background. In Kenya, variants of this fourth selective sweep have differentiated and become endemic residing in and emerging from environmental reservoirs. On a local level, studies in Bangladesh have revealed that outbreaks may arise from a nonrandom subset of the genetic lineages in the environment and as the population of the pathogen expands, many novel mutations may be found increasing the amount of genetic variation, a phenomenon known as a founder flush. In Haiti, after the initial invasion and expansion of V. cholerae in 2010, a second outbreak occurred in the winter of 2011–2012 driven by natural selection of specific mutations.
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影响因子：
11.4
作者：
BIK, EM;BUNSCHOTEN, AE;MOOI, FR
通讯作者：
MOOI, FR
影响因子：
3.6
作者：
Comstock, LE;Johnson, JA;Kaper, JB
通讯作者：
Kaper, JB
DOI：
10.1073/pnas.1019712108
发表时间：
2011-05-24
影响因子：
11.1
作者：
Mukandavire, Zindoga;Liao, Shu;Morris, J Glenn Jr
通讯作者：
Morris, J Glenn Jr
影响因子：
11.8
作者：
Mohamed, Ahmed Abade;Oundo, Joseph;Stine, O. Colin
通讯作者：
Stine, O. Colin
影响因子：
3.7
作者：
Jubair M;Morris JG Jr;Ali A
通讯作者：
Ali A