Endogenous opioid peptides and cardiac arrhythmias.
Endogenous opioid peptides and cardiac arrhythmias.
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内源性阿片肽和心律失常。
DOI：
10.1016/0167-5273(90)90152-u
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发表时间：
1990
影响因子：
3.5
通讯作者：
A. F. Lee
中科院分区：
文献类型：
--
作者：
A. F. Lee
有大量证据表明，在阿片肽或心肌缺血再灌注引起的心律失常期间，心脏阿片受体被激活，支持内源性阿片肽参与心律失常发生的假设[l-lo]。心律失常的发生伴随着心肌单磷酸环腺苷水平的升高，这表明环核苷酸与心律失常之间可能存在功能关系[1 -141]。一个明显的假设是，心肌缺血再灌注通过增加阿片肽从心脏释放来激活心肌阿片受体，从而导致心肌环磷酸腺苷水平升高[15,16]，从而通过离子通道的改变引起心律失常[17-191]。在这篇综述中，我讨论了内源性阿片肽在心律失常发生中的可能作用。
There is substantial evidence that cardiac opiate receptors are activated during arrhythmias induced by administration of opioid peptides or myocardial ischemia and reperfusion, supporting the hypothesis that endogenous opioid peptides are involved in cardiac arrhythmogenesis[l-lo]. The occurrence of arrhythmias is accompanied by an increase in myocardial levels of cyclic adenosine monophosphate which suggests a possible functional relationship between the cyclic nucleotide and cardiac arrhythmias [ll-141. An obvious hypothesis is that myocardial ischemia and reperfusion activates the myocardial opiate receptors through an increased release of opioid peptides from the heart, which in turn leads to an increase in myocardial levels of cyclic adenosine monophosphate[15, 16], thereby causing arrhythmias through alteration of the ionic channels [17-191. In this review, I have discussed the possible roles of endogenous opioid peptides in cardiac arrhythmogenesis.
大鼠脑中α-新内啡肽/强啡肽神经元系统的免疫组织化学分布：共定位的证据。
DOI：
10.1073/pnas.79.9.3062
发表时间：
1982
影响因子：
11.1
作者：
Weber,E;Roth,KA;Barchas,JD
通讯作者：
Barchas,JD
DOI：
10.1073/pnas.77.10.6239
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GOODMAN, RR;SNYDER, SH;YOUNG, WS
通讯作者：
YOUNG, WS
DOI：
10.1177/28.8.7003009
发表时间：
1980
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Miller,RJ;Pickel,VM
通讯作者：
Pickel,VM