Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials.
Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials.
复制标题
DOI：
10.1016/j.colsurfb.2013.04.043
复制
发表时间：
2013-10-01
影响因子：
5.8
通讯作者：
Sun, Yuyu
中科院分区：
文献类型：
--
作者：
Sun, Xinbo;Cao, Zhengbing;Yeh, Chih-Ko;Sun, Yuyu
念珠菌在假牙表面的定植和生物膜形成导致念珠菌相关性假牙口炎（CADS），这是一种常见的复发性疾病，影响多达67%的假牙佩戴者。我们研制了可反复充注各种抗真菌药物的聚（n -乙烯基-2-吡咯烷酮）义齿材料，达到长期的抗真菌和生物膜控制效果。将n -乙烯基-2-吡罗烷酮（NVP）单体通过等离子体引发接枝聚合接枝到聚甲基丙烯酸甲酯义齿树脂上。高达7.92%的接枝聚（n -乙烯基-2-吡罗烷酮）（PNVP）的存在对树脂的物理性能和生物相容性没有负面影响。以咪康唑和二光酸氯己定（CD）为模型抗真菌药物。PNVP移植明显提高了义齿材料的药物吸收能力。此外，新材料显示出持续的药物释放，并提供数周（在乳糜泻的情况下）到数月（在咪康唑的情况下）的抗真菌效果。用相同或不同种类的抗真菌药物对药物耗尽的树脂进行充注，以进一步延长抗真菌时间。如果需要，可以通过PNVP水溶液处理将PNVP义齿材料上的药物“冲掉”（淬灭），以阻止药物释放。这些结果指出了新材料在控制生物膜形成方面的巨大潜力，在广泛的设备相关应用中。
Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be “washed out” (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.
登录
查看更多内容
影响因子：
4.6
作者：
BAUMAN, R
通讯作者：
BAUMAN, R
影响因子：
1.7
作者：
Cao, Zhengbing;Sun, Xinbo;Fong, Hao
通讯作者：
Fong, Hao
影响因子：
2.1
作者：
JEGANATHAN, S;LIN, CC
通讯作者：
LIN, CC
影响因子：
2.6
作者：
DOUGLAS, WH;WALKER, DM
通讯作者：
WALKER, DM
影响因子：
5.6
作者：
Chladek G;Mertas A;Barszczewska-Rybarek I;Nalewajek T;Zmudzki J;Król W;Lukaszczyk J
通讯作者：
Lukaszczyk J