Novel assessment of acute lung injury by in vivo near-infrared spectroscopy.
Novel assessment of acute lung injury by in vivo near-infrared spectroscopy.
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通过体内近红外光谱对急性肺损伤的新评估。
DOI：
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发表时间：
1999
影响因子：
24.7
通讯作者：
Kiyohiko Dohi
中科院分区：
文献类型：
--
作者：
Satoshi Shibata;Hideki Ohdan;Toshio Noriyuki;Shinkichirou Yoshioka;T. Asahara;Kiyohiko Dohi
探讨近红外光谱技术在急性肺损伤（ALI）诊断中的可行性和有效性。在模拟肺的分光光度特征的体外模型中，NIR光谱可以精确地检测水量的变化，表明其能够评估ALI引起的肺水肿的程度。采用油酸诱导大鼠不同程度的急性肺损伤模型，采用近红外光谱法测定肺含水量和血红蛋白（Hb）氧合。近红外光谱检测增加的水含量，即使在组织学轻度ALI。通过NIR光谱测量的肺含水量的变化与重量肺含水量显著相关（r = 0.877，p < 0.0001）。近红外光谱法测定的脱氧血红蛋白一致地反映了肺组织学变化，脱氧血红蛋白水平与血氧饱和度变化相关（r =-0.798，p < 0.0001）。这些结果表明，近红外光谱可以定量评估肺水含量和血红蛋白氧合，并可能是一个有用的工具，评估病理状态的ALI。
We investigated the feasibility and validity of near-infrared (NIR) spectroscopy for evaluation of acute lung injury (ALI). In an in vitro model simulating the spectrophotometric characteristics of the lung, NIR spectroscopy could precisely detect changes in water volume, suggesting its ability to assess the extent of pulmonary edema caused by ALI. The different grades of ALI were induced in rats by administering oleic acid and varying the pulmonary ventilation conditions, and NIR spectroscopy was employed to determine lung water content and hemoglobin (Hb) oxygenation of the lungs. NIR spectroscopy detected increased water content even in histologically mild ALI. The changes in lung water content measured by NIR spectroscopy were significantly correlated with gravimetric lung water content (r = 0.877, p < 0.0001). Deoxy-Hb measured by NIR spectroscopy consistently reflected the histological changes in the lungs, and the deoxy-Hb levels correlated with changes in SaO2 (r = -0.798, p < 0.0001). These findings demonstrate that NIR spectroscopy can evaluate lung water content and Hb oxygenation quantitatively, and may be a useful tool for assessing pathological status in ALI.
DOI：
10.1152/jappl.1985.58.1.97
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Suzuki,S;Butler,JP;Oldmixon,EH;HoppinJr,FG
通讯作者：
HoppinJr,FG
DOI：
10.1164/ajrccm/137.6.1371
发表时间：
1988
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Cutillo,AG;Morris,AH;Ailion,DC;Case,TA;Durney,CH;Ganesan,K;Watanabe,F;Akhtari,M
通讯作者：
Akhtari,M
机械通气增加油酸损伤肺部的微血管通透性。
DOI：
10.1152/jappl.1990.69.6.2057
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Hernandez,LA;Coker,PJ;May,S;Thompson,AL;Parker,JC
通讯作者：
Parker,JC