Detection of quantitative trait loci from frequency changes of marker alleles under selection.
Detection of quantitative trait loci from frequency changes of marker alleles under selection.
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根据选择下标记等位基因的频率变化检测数量性状基因座。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Grahame Bulfield
中科院分区：
文献类型：
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作者：
P. Keightley;Grahame Bulfield
基于标记与QTL完全连锁的加性模型，提出了一种利用被选择标记基因频率变化信息，用极大似然法估计QTL效应的方法。应用该方法对两个自交系F2代的16个分子标记和毛色标记座位的数据进行了分析，这两个自交系在6周龄体重上进行了21代的不同选择。在基因组的4个区域中，标记等位基因的频率比取样所能解释的更极端，这意味着在附近的QTL上进行了选择。约0.5个标准差的效应位于第11号染色体上，对基础群体的遗传方差的贡献率接近10%。可以检测到效应小到0.2的表型标准差的QTL。对于给定数量的个体进行分型，与分析F2群体相比，QTL的检测能力非常高。通过蒙特卡罗模拟研究了连锁和选择的联合效应。标记基因频率几乎不受QTL选择的影响，除非标记和QTL之间的距离小于20 cM。
A method was developed to estimate effects of quantitative trait loci (QTL) by maximum likelihood using information from changes of gene frequency at marker loci under selection, assuming an additive model of complete linkage between markers and QTL. The method was applied to data from 16 molecular and coat colour marker loci in mouse lines derived from the F2 of two inbred strains which were divergently selected on 6-week weight for 21 generations. In 4 regions of the genome, marker allele frequencies were more extreme than could be explained by sampling, implying selection at nearby QTL. An effect of about 0.5 standard deviations was located on chromosome 11, and accounted for nearly 10% of the genetic variance in the base population. QTL with effects as small as 0.2 phenotypic standard deviations could be detected. For typing of a given number of individuals, the power of detection of QTL is very high compared to, for example, analysis of an F2 population. The joint effects of linkage and selection were investigated by Monte Carlo simulation. Marker gene frequencies change little as a consequence of selection at a QTL unless the marker and QTL are less than about 20 cM apart.
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影响因子：
--
作者：
G. Pfeifer;A. Riggs
通讯作者：
G. Pfeifer;A. Riggs
使用分子标记鉴定导致两个优良玉米自交系杂种优势的遗传因素。
影响因子：
3.3
作者：
Stuber,CW;Lincoln,SE;Wolff,DW;Helentjaris,T;Lander,ES
通讯作者：
Lander,ES
内源性小鼠白血病原病毒的连锁图。
影响因子：
3.3
作者：
Frankel,WN;Stoye,JP;Taylor,BA;Coffin,JM
通讯作者：
Coffin,JM
适合进行种内杂交分型的小鼠遗传图谱。
影响因子：
3.3
作者：
Dietrich,W;Katz,H;Lincoln,SE;Shin,HS;Friedman,J;Dracopoli,NC;Lander,ES
通讯作者：
Lander,ES