Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids.
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids.
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拟寄生物果蝇进入太空：太空飞行对寄主及其拟寄生物的意外影响。
DOI：
10.1016/j.isci.2023.108759
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发表时间：
2024-01-19
期刊：
影响因子：
5.8
通讯作者：
Govind, Shubha
中科院分区：
文献类型：
--
作者：
Chou, Jennifer;Ramroop, Johnny R.;Saravia-Butler, Amanda M.;Wey, Brian;Lera, Matthew P.;Torres, Medaya L.;Heavner, Mary Ellen;Iyer, Janani;Mhatre, Siddhita D.;Bhattacharya, Sharmila;Govind, Shubha
虽然果蝇(黑腹果蝇)和人类在太空中表现出免疫系统功能障碍，但缺乏研究它们的免疫系统与太空中自然寄生虫的相互作用。果蝇类寄生蜂通过改变血细胞功能来抑制宿主免疫。在这项研究中，检测了来自无肿瘤对照和血液携带肿瘤突变株的幼稚和寄生的地面和太空苍蝇。在两种苍蝇品系中，炎症相关基因在太空中都被激活。而对照果蝇没有发生肿瘤，而太空返回的携带肿瘤的突变体的肿瘤负担增加了。令人惊讶的是，对照果蝇比变异果蝇对太空飞行更敏感；它们的许多基本基因都下调了。寄生蜂似乎比苍蝇宿主更具弹性，航天飞行对黄蜂的生存或其毒力基因的表达没有显著影响。此前没有文献记载的具有新的翅膀颜色和翅膀形状的突变黄蜂在飞行后被分离出来，这对地球上的寄主-寄生虫研究将是无价的。航天飞行促进果蝇免疫基因表达和肿瘤发展果蝇类寄生蜂在太空中发育不会丧失毒力寄生突变体获得寄生虫学；生物科学；昆虫学
While fruit flies (Drosophila melanogaster) and humans exhibit immune system dysfunction in space, studies examining their immune systems’ interactions with natural parasites in space are lacking. Drosophila parasitoid wasps modify blood cell function to suppress host immunity. In this study, naive and parasitized ground and space flies from a tumor-free control and a blood tumor-bearing mutant strain were examined. Inflammation-related genes were activated in space in both fly strains. Whereas control flies did not develop tumors, tumor burden increased in the space-returned tumor-bearing mutants. Surprisingly, control flies were more sensitive to spaceflight than mutant flies; many of their essential genes were downregulated. Parasitoids appeared more resilient than fly hosts, and spaceflight did not significantly impact wasp survival or the expression of their virulence genes. Previously undocumented mutant wasps with novel wing color and wing shape were isolated post-flight and will be invaluable for host-parasite studies on Earth. Spaceflight enhances immune gene expression and tumor development in fruit flies Drosophila parasitoid wasps can develop in space without losing virulence Parasitoid mutants with visible alterations were obtained Parasitology; Biological sciences; Entomology
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影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
3.3
作者：
Gramates LS;Agapite J;Attrill H;Calvi BR;Crosby MA;Dos Santos G;Goodman JL;Goutte-Gattat D;Jenkins VK;Kaufman T;Larkin A;Matthews BB;Millburn G;Strelets VB;the FlyBase Consortium
通讯作者：
the FlyBase Consortium
影响因子：
--
作者：
Davis MN;Horne-Badovinac S;Naba A
通讯作者：
Naba A
影响因子：
64.5
作者：
DECICCO, DV;SPRADLING, AC
通讯作者：
SPRADLING, AC
影响因子：
11.5
作者：
Banerjee S;Biehl A;Gadina M;Hasni S;Schwartz DM
通讯作者：
Schwartz DM