The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.
The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.
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DOI：
10.1002/wdev.77
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发表时间：
2012-11
影响因子：
--
通讯作者：
Xu, Suhong
中科院分区：
文献类型：
--
作者：
Chisholm, Andrew D.;Xu, Suhong
梭线虫表皮形成动物的主要屏障上皮之一。表皮的分化开始于胚胎发育中期，涉及细胞骨架和分泌系统的顶基极化以及细胞连接的形成。外角质层的分泌是表皮上皮的主要发育和生理特化之一。四个胚胎后幼虫阶段被周期性蜕皮分开，在蜕皮中，表皮产生具有阶段特异性特征的新角质层。分化的表皮也在内分泌信号、脂肪储存和离子稳态中起关键作用。表皮与神经系统的发育和功能密切相关，并且可能在调节神经元功能中具有神经胶质样作用。表皮提供被动和主动防御皮肤穿透病原体，并可以修复小伤口。最后，表皮的年龄依赖性退化是衰老的一个突出特征，并可能影响生物体衰老和寿命。
The C. elegans epidermis forms one of the principal barrier epithelia of the animal. Differentiation of the epidermis begins in mid embryogenesis and involves apical-basal polarization of the cytoskeletal and secretory systems as well as cellular junction formation. Secretion of the external cuticle layers is one of the major developmental and physiological specializations of the epidermal epithelium. The four post-embryonic larval stages are separated by periodic moults, in which the epidermis generates a new cuticle with stage-specific characteristics. The differentiated epidermis also plays key roles in endocrine signaling, fat storage, and ionic homeostasis. The epidermis is intimately associated with the development and function of the nervous system, and may have glial-like roles in modulating neuronal function. The epidermis provides passive and active defenses against skin-penetrating pathogens and can repair small wounds. Finally, age-dependent deterioration of the epidermis is a prominent feature of aging and may affect organismal aging and lifespan.
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影响因子：
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