C. elegans multi-dendritic sensory neurons: morphology and function.
C. elegans multi-dendritic sensory neurons: morphology and function.
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DOI：
10.1016/j.mcn.2010.10.001
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发表时间：
2011-01
影响因子：
3.5
通讯作者：
Treinin, Millet
中科院分区：
文献类型：
--
作者：
Albeg, Adi;Smith, Cody J.;Chatzigeorgiou, Marios;Feitelson, Dror G.;Hall, David H.;Schafer, William R.;Miller, David M., III;Treinin, Millet
PVD和FLP感觉神经元包裹着线虫成虫的身体，具有高度分枝的细感觉突起网络。PVD和FLP神经元都是机械感受器。众所周知，PVD介导了对高阈值机械刺激的反应。因此，PVD和FLP神经元在形态和功能上与哺乳动物的伤害性感受器相似。为了更好地了解这些神经元的功能，我们产生了缺乏它们的菌株。行为学分析表明，PVD和FLP在正常生长条件下调节运动，因为缺乏这些神经元的动物表现出更高的栖息行为。此外，PVD--其细小的分支贯穿全身肌肉--可能在本体感觉中起作用，因为PVD的消融会导致姿势缺陷。此外，在PVD中可以看到运动依赖的钙瞬变，这一反应需要MEC-10，这是机械感觉DEG/ENaC通道的一个亚单位，也是维持野生型姿势所必需的。因此，PVD同时感知有害和无害信号来调节线虫的行为，从而结合了多个哺乳动物体感神经元的功能。最后，强烈的机械刺激导致产卵抑制，这种反应还依赖于PVD和FLP神经元。基于所有这些结果，我们认为PVD和FLP感受到的有害信号促进了一种逃逸行为，包括速度加快、停顿和反转减少以及产卵抑制。
PVD and FLP sensory neurons envelope the body of the C. elegans adult with a highly branched network of thin sensory processes. Both PVD and FLP neurons are mechanosensors. PVD is known to mediate the response to high threshold mechanical stimuli. Thus PVD and FLP neurons are similar in both morphology and function to mammalian nociceptors. To better understand the function of these neurons we generated strains lacking them. Behavioral analysis shows that PVD and FLP regulate movement under normal growth conditions, as animals lacking these neurons demonstrate higher dwelling behavior. In addition, PVD—whose thin branches project across the body-wall muscles—may have a role in proprioception, as ablation of PVD leads to defective posture. Moreover, movement-dependent calcium transients are seen in PVD, a response that requires MEC-10, a subunit of the mechanosensory DEG/ENaC channel that is also required for maintaining wild-type posture. Hence, PVD senses both noxious and innocuous signals to regulate C. elegans behavior, and thus combines the functions of multiple mammalian somatosensory neurons. Finally, strong mechanical stimulation leads to inhibition of egg-laying, and this response also depends on PVD and FLP neurons. Based on all these results we suggest that noxious signals perceived by PVD and FLP promote an escape behavior consisting of increased speed, reduced pauses and reversals, and inhibition of egg-laying.
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影响因子：
11.4
作者：
FIRE, A;WATERSTON, RH
通讯作者：
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作者：
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