High resolution map of Caenorhabditis elegans gap junction proteins.
High resolution map of Caenorhabditis elegans gap junction proteins.
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DOI：
10.1002/dvdy.22025
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发表时间：
2009-08
影响因子：
2.5
通讯作者：
Hall, David H.
中科院分区：
文献类型：
--
作者：
Altun, Zeynep F.;Chen, Bojun;Wang, Zhao-Weng;Hall, David H.
在秀丽隐杆线虫中，间隙连接蛋白的连接蛋白家族有25个成员。在这里，我们通过分析在整个启动子区域控制下用绿色荧光蛋白转化的活蠕虫，描述了所有成员的第一个高分辨率表达图谱。我们的分析表明，innexins在整个发育过程中具有动态表达模式，并且几乎存在于所有细胞类型和组织中。复杂的组织，如咽、肠、性腺以及支架组织和导柱细胞，以重叠或互补的方式表达多种内联蛋白，表明它们可能形成异聚和异型通道。Innexin的表达出现在几种不形成间隙连接的细胞中，也出现在一对迁移细胞中，这表明它们可能具有半通道功能。因此，肠内肽可能在几乎所有的身体功能中发挥作用，包括胚胎发育、细胞命运决定、卵发生、产卵、咽泵、排泄和运动。
The innexin family of gap junction proteins has 25 members in Caenorhabditis elegans. Here, we describe the first high-resolution expression map of all members through analysis of live worms transformed with green fluorescent protein under the control of entire promoter regions. Our analyses show that innexins have dynamic expression patterns throughout development and are found in virtually all cell types and tissues. Complex tissues, such as the pharynx, intestine, gonad, as well as scaffolding tissues and guidepost cells express a variety of innexins in overlapping or complementary patterns, suggesting they may form heteromeric and heterotypic channels. Innexin expression occurs in several types of cells that are not known to form gap junctions as well as in a pair of migrating cells, suggesting they may have hemichannel function. Therefore, innexins likely play roles in almost all body functions, including embryonic development, cell fate determination, oogenesis, egg laying, pharyngeal pumping, excretion, and locomotion.
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DOI：
10.1073/pnas.2233464100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Bruzzone, R;Hormuzdi, SG;Monyer, H
通讯作者：
Monyer, H
影响因子：
2.7
作者：
KIMBLE, JE;WHITE, JG
通讯作者：
WHITE, JG
影响因子：
56.9
作者：
Aurelio, O;Hall, DH;Hobert, O
通讯作者：
Hobert, O
影响因子：
2.7
作者：
BOSSINGER, O;SCHIERENBERG, E
通讯作者：
SCHIERENBERG, E
影响因子：
2.7
作者：
Buechner, M;Hall, DH;Hedgecock, EM
通讯作者：
Hedgecock, EM