Gemfibrozil lowers plasma lipids and increases polyunsaturated fatty acid content and oxidative susceptibility of lipoproteins in hypertriglyceridemia.
Gemfibrozil lowers plasma lipids and increases polyunsaturated fatty acid content and oxidative susceptibility of lipoproteins in hypertriglyceridemia.
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吉非罗齐可降低高甘油三酯血症患者的血浆脂质并增加多不饱和脂肪酸含量和脂蛋白的氧化敏感性。
DOI：
10.1016/s0009-8981(02)00129-8
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
F. Faas
中科院分区：
文献类型：
--
作者：
W. Smith;Jiang;A. Dang;C. Reeves;D. Bibbs;F. Faas
根纤维齐是治疗高甘油三酯血症的有效药物，其对发病率和死亡率的影响似乎与其降脂作用不成比例。它对脂蛋白脂肪酸组成的潜在影响及其对氧化易感性的影响引起了相当大的兴趣。关于吉非齐尔是否会改变人体脂质组成或脂蛋白的氧化易感性，实验结果尚无定论。在这里，我们使用不同的方法来调查这个问题，而不是在以前的调查中使用。方法：即使是高甘油三酯血症患者也完成了为期12周的吉非罗齐治疗（600 mg，每日两次），旨在初步评估与脂肪酸谱变化相关的脂蛋白氧化易感性的新方法。我们测量了血浆大分子部分中脂蛋白对铜介导氧化的敏感性。此外，血浆脂质被分离为磷脂（PL）、胆固醇酯（CE）和甘油三酯（TG）部分，并通过气液色谱法测定了这三类脂肪酸的组成。脂质浓度、脂肪酸组成和氧化参数（主要是滞后时间）的变化之间的关系通过相关分析进行检验。结果吉非罗齐对甘油三酯浓度和总胆固醇浓度有较好的反应（分别降低55%和15%）。多不饱和脂肪酸（PUFA）在血浆脂质胆固醇酯和磷脂组分中的比例显著增加，而饱和脂肪酸（SFA）和单不饱和脂肪酸（MUFA）的比例则显著降低。氧化参数也发生了显著变化。滞后时间（LT）和最大氧化程度的变化最为显著。延迟时间是测定脂蛋白对氧化敏感性的主要指标，吉非罗齐降低了延迟时间。磷脂和胆固醇酯中多不饱和脂肪酸含量的增加与滞后时间的减少显著相关。结论：这些数据支持吉非纤维齐增加血浆脂质中多不饱和脂肪酸的比例的观点，这种增加与高甘油三酯血症延迟时间测量的脂蛋白氧化易感性的增加有关。
BackgroundGemfibrozil is an effective drug in the treatment of hypertriglyceridemia and its effects on morbidity and mortality seem out of proportion to its lipid lowering actions. There is considerable interest in its potential effects on lipoprotein fatty acid composition and consequent effect on oxidative susceptibility. Experimental results are not conclusive regarding whether gemfibrozil alters lipid composition or oxidative susceptibility of lipoproteins in humans. Here we investigate this question using different methodology than employed in previous investigations.MethodsEleven hypertriglyceridemic individuals completed a 12-week course of gemfibrozil therapy (600 mg twice daily) intended to primarily evaluate a new way of assessing lipoprotein susceptibility to oxidation in relation to changes in the fatty acid profile. We measured susceptibility of lipoproteins in the plasma macromolecule fraction to copper-mediated oxidation. In addition, plasma lipids were separated into phospholipid (PL), cholesterol ester (CE) and triglyceride (TG) fractions and the fatty acid composition of these classes determined by gas–liquid chromatography. The relation between changes in lipid concentration, fatty acid composition and oxidative parameters (principally lag time) was examined by correlational analysis.ResultsTriglyceride concentrations and total cholesterol concentrations responded appropriately to gemfibrozil (lowered by 55% and 15%, respectively). Polyunsaturated fatty acid (PUFA) proportion increased significantly in cholesterol ester and phospholipid fractions of plasma lipids at the expense of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA). Oxidative parameters also changed significantly. Lag time (LT) and maximal extent of oxidation showed the most significant changes. Lag time, the principle measure of lipoprotein susceptibility to oxidation, was decreased by gemfibrozil. The increase in polyunsaturated fatty acid content in phospholipid and cholesterol ester significantly correlated with decreased lag time.ConclusionThese data support the notion that gemfibrozil increases the proportion of polyunsaturated fatty acids in plasma lipids and that this increase is associated with an increase in lipoprotein oxidative susceptibility as measured by lag time in hypertriglyceridemia.
使用富含油酸的饮食来降低人类低密度脂蛋白对氧化修饰的敏感性的可行性。
DOI：
10.1093/ajcn/54.4.701
发表时间：
1991
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Reaven,P;Parthasarathy,S;Grasse,BJ;Miller,E;Almazan,F;Mattson,FH;Khoo,JC;Steinberg,D;Witztum,JL
通讯作者：
Witztum,JL
超越胆固醇。
DOI：
10.1056/nejm198904063201407
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
Steinberg,D;Parthasarathy,S;Carew,TE;Khoo,JC;Witztum,JL
通讯作者：
Witztum,JL
DOI：
10.1073/pnas.87.10.3894
发表时间：
1990-05-01
影响因子：
11.1
作者：
PARTHASARATHY, S;KHOO, JC;STEINBERG, D
通讯作者：
STEINBERG, D