Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: a prospective observational cohort study.

Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: a prospective observational cohort study.
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DOI:
10.1186/1471-2393-14-201
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发表时间:
2014-06-11
影响因子:
3.1
通讯作者:
Meltzer HM
Meltzer HM
中科院分区:
医学3区
文献类型:
--
作者:
Haugen M;Brantsæter AL;Winkvist A;Lissner L;Alexander J;Oftedal B;Magnus P;Meltzer HM

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妊娠期体重过度增加(GWG)与妊娠并发症有关,挪威卫生当局已采纳美国医学研究所和国家研究理事会(IOM)的GWG建议。本研究的目的是评估在挪威人群中,IOM建议之外的GWG是否与妊娠并发症(如高血压、低出生体重和高出生体重、先兆子痫、紧急剖腹产和6个月和18个月时的产妇产后体重保留(PPWR))风险增加相关。这项研究是在1999年至2008年的挪威国家母亲和儿童队列研究(MoBa)中纳入的56101名孕妇中进行的。纳入了在妊娠第37至42周期间分娩单胎活产婴儿的妇女。在妊娠第17周和产后6个月和18个月,通过问卷调查收集孕妇孕前和产后体重。体重增加低于IOM建议(GWG < IOM建议)增加了正常体重未经产妇生下低体重婴儿的风险。体重增加高于IOM建议(GWG > IOM建议)显著增加了未经产和经产正常体重妇女的妊娠高血压、高出生体重婴儿、先兆子痫和紧急剖宫产的风险。超重妇女的结果相似,但GWG > IOM rec.的经产妇女妊娠期高血压风险没有增加。74%的超重未经产妇女和66%的肥胖妇女GWG> IOM rec.导致所有体重类别中PPWR > 2 kg的风险增加,但大多数妇女在产后18个月达到其怀孕前的体重等级。对于孕前正常体重和超重的妇女,GWG > IOM建议增加了未经产和经产妇女不良分娩结局的风险。在所有体重类别中,GWG > IOM建议在18个月时增加PPWR > 2 kg的风险。这项大型研究支持挪威卫生当局对正常体重和超重妇女遵守IOM建议的建议。
Excessive gestational weight gain (GWG) is associated with pregnancy complications, and Norwegian Health Authorities have adopted the GWG recommendations of the US Institute of Medicine and National Research Council (IOM). The aim of this study was to evaluate if a GWG outside the IOM recommendation in a Norwegian population is associated with increased risk of pregnancy complications like hypertension, low and high birth weight, preeclampsia, emergency caesarean delivery, and maternal post-partum weight retention (PPWR) at 6 and 18 months. This study was performed in 56 101 pregnant women included in the prospective national Norwegian Mother and Child Cohort Study (MoBa) in the years 1999 to 2008. Women who delivered a singleton live born child during gestational week 37 to 42 were included. Maternal prepregnant and postpartum weight was collected from questionnaires at 17th week of gestation and 6 and 18 months postpartum. A weight gain less than the IOM recommendations (GWG < IOM rec.) increased the risk for giving birth to a low weight baby among normal weight nulliparous women. A weight gain higher than the IOM recommendations (GWG > IOM rec.) significantly increased the risk of pregnancy hypertension, a high birth weight baby, preeclampsia and emergency cesarean delivery in both nulliparous and parous normal weight women. Similar results were found for overweight women except for no increased risk for gestational hypertension in parous women with GWG > IOM rec. Seventy-four percent of the overweight nulliparous women and 66% of the obese women had a GWG > IOM rec. A GWG > IOM rec. resulted in increased risk of PPWR > 2 kg in all weight classes, but most women attained their prepregnant weight class by 18 months post-partum. For prepregnant normal weight and overweight women a GWG > IOM rec. increased the risk for unfavorable birth outcomes in both nulliparous and parous women. A GWG > IOM rec. increased the risk of a PPWR > 2 kg at 18 months in all weight classes. This large study supports the Norwegian Health authorities’ recommendations for normal weight and overweight women to comply with the IOM rec.
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