Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
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DOI：
10.1007/s00335-010-9284-4
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发表时间：
2010-10
期刊：
影响因子：
2.5
通讯作者：
Maltais, Lois J.
中科院分区：
文献类型：
--
作者：
Holmes, Roger S.;Wright, Matthew W.;Laulederkind, Stanley J. F.;Cox, Laura A.;Hosokawa, Masakiyo;Imai, Teruko;Ishibashi, Shun;Lehner, Richard;Miyazaki, Masao;Perkins, Everett J.;Potter, Phillip M.;Redinbo, Matthew R.;Robert, Jacques;Satoh, Tetsuo;Yamashita, Tetsuro;Yan, Bingfan;Yokoi, Tsuyoshi;Zechner, Rudolf;Maltais, Lois J.
哺乳动物羧酸酯酶（CES或Ces）基因编码参与体内异生物质、药物和脂质代谢的酶，并且是至少五个基因家族的成员。串联重复为某些家族增加了更多的基因，特别是小鼠和大鼠的基因组，这在命名啮齿动物Ces基因时造成了混乱。本文介绍了一种新的命名系统，人类，小鼠和大鼠羧酸酯酶基因，确定同源基因家族，并分配一个独特的名称为每个基因。遵循人、小鼠和大鼠基因命名委员会的指导方针，并且使用“CES”（人）和“Ces”（小鼠和大鼠）根符号，然后是家族编号（例如，人CES 1）。当一个家族鉴定出多个基因或与现有基因名称发生冲突时，添加一个字母（例如，人CES 4A;小鼠和大鼠Ces 1a），其反映了啮齿动物物种之间的基因相关性（例如，小鼠和大鼠Ces 1a）。假基因通过在人类基因名称中添加“P”和数字来命名（例如，人CES 1 P1）或使用新字母后接ps表示小鼠和大鼠Ces假基因（例如，Ces2d-ps）。通过将GenBank登录ID添加到基因符号来命名基因转录物同种型（例如，人CES1_AB119995或小鼠Ces1e_BC019208）。这种命名法提高了我们对人类、小鼠和大鼠CES/Ces基因家族的理解，并促进了对这些基因家族的结构、功能和进化的研究。它也是命名其他哺乳动物CES基因的模型。
Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in xenobiotic, drug, and lipid metabolism in the body and are members of at least five gene families. Tandem duplications have added more genes for some families, particularly for mouse and rat genomes, which has caused confusion in naming rodent Ces genes. This article describes a new nomenclature system for human, mouse, and rat carboxylesterase genes that identifies homolog gene families and allocates a unique name for each gene. The guidelines of human, mouse, and rat gene nomenclature committees were followed and “CES” (human) and “Ces” (mouse and rat) root symbols were used followed by the family number (e.g., human CES1). Where multiple genes were identified for a family or where a clash occurred with an existing gene name, a letter was added (e.g., human CES4A; mouse and rat Ces1a) that reflected gene relatedness among rodent species (e.g., mouse and rat Ces1a). Pseudogenes were named by adding “P” and a number to the human gene name (e.g., human CES1P1) or by using a new letter followed by ps for mouse and rat Ces pseudogenes (e.g., Ces2d-ps). Gene transcript isoforms were named by adding the GenBank accession ID to the gene symbol (e.g., human CES1_AB119995 or mouse Ces1e_BC019208). This nomenclature improves our understanding of human, mouse, and rat CES/Ces gene families and facilitates research into the structure, function, and evolution of these gene families. It also serves as a model for naming CES genes from other mammalian species.
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影响因子：
0.7
作者：
Holmes RS;Glenn JP;VandeBerg JL;Cox LA
通讯作者：
Cox LA
影响因子：
1.5
作者：
Holmes, Roger S.;Cox, Laura A.;VandeBerg, John L.
通讯作者：
VandeBerg, John L.
影响因子：
5.6
作者：
Fleming, CD;Bencharit, S;Redinbo, MR
通讯作者：
Redinbo, MR
DOI：
10.1016/s0006-291x(88)80513-8
发表时间：
1988-03-30
影响因子：
3.1
作者：
GENETTA, TL;DEUSTACHIO, P;FINLAY, TH
通讯作者：
FINLAY, TH
影响因子：
2.1
作者：
Hosokawa, Masakiyo;Furihata, Tomomi;Chiba, Kan
通讯作者：
Chiba, Kan