Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases.
Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases.
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DOI：
10.1111/j.1600-0684.2008.00315.x
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发表时间：
2009-02
影响因子：
0.7
通讯作者：
Cox LA
中科院分区：
文献类型：
--
作者：
Holmes RS;Glenn JP;VandeBerg JL;Cox LA
羧酸酯酶 (CES) 主要负责多种药物和麻醉剂的解毒，并催化胆固醇和脂肪酸代谢中的多种反应。对灵长类动物 CES 遗传和生化特性的研究可能有助于增进对人类疾病的了解，包括动脉粥样硬化、肥胖和药物成瘾，非人类灵长类动物可作为有用的动物模型。我们对狒狒 CES1 和 CES2 进行了克隆和测序，并使用体外和计算机方法来预测蛋白质二级和三级结构，并检查了这些酶与其他灵长类动物和小鼠 CES 直系同源物的进化关系。我们发现狒狒CES1和CES2蛋白与人类CES1和CES2保持广泛的相似性，共享人类CES1报道的关键结构特征，并显示出分别与其多聚体和单体亚基结构一致的家族特异性序列。
Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including atherosclerosis, obesity and drug addiction, for which non-human primates serve as useful animal models. We cloned and sequenced baboon CES1 and CES2 and used in vitro and in silico methods to predict protein secondary and tertiary structures, and examined evolutionary relationships for these enzymes with other primate and mouse CES orthologs. We found that baboon CES1 and CES2 proteins retained extensive similarity with human CES1 and CES2, shared key structural features reported for human CES1, and showed family specific sequences consistent with their multimeric and monomeric subunit structures respectively.
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影响因子：
14.9
作者：
Kopp, J;Schwede, T
通讯作者：
Schwede, T
影响因子：
5.6
作者：
Fleming, CD;Bencharit, S;Redinbo, MR
通讯作者：
Redinbo, MR
影响因子：
56.9
作者：
Gibbs, Richard A.;Rogers, Jeffrey;Zwieg, Ann S.
通讯作者：
Zwieg, Ann S.
影响因子：
5.6
作者：
Bencharit, Sompop;Edwards, Carol C.;Redinbo, Matthew R.
通讯作者：
Redinbo, Matthew R.
DOI：
10.1016/0305-0491(85)90475-4
发表时间：
1985-01-01
影响因子：
2.2
作者：
BERNING, W;DELOOZE, SM;VONDEIMLING, O
通讯作者：
VONDEIMLING, O