Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model.
Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model.
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DOI：
10.1155/2012/161527
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Soelaiman IN
中科院分区：
文献类型：
--
作者：
Muhammad N;Luke DA;Shuid AN;Mohamed N;Soelaiman IN
绝经后骨质疏松性骨丢失主要是由于卵巢功能的停止，这是一种与自由基增加有关的疾病。维生素E是一种脂溶性维生素，是一种有效的抗氧化剂，可以抑制体内的自由基。在这项研究中，我们研究了α-生育酚和纯生育三烯酚对卵巢切除大鼠骨微结构和细胞参数的影响。将三个月大的雌性Wistar大鼠随机分为卵巢切除对照组、假手术组和用α-生育酚或生育三烯酚治疗的卵巢切除大鼠。在四周的研究期结束时，取他们的股骨进行骨组织形态计量学分析。卵巢切除术导致对照组骨丢失，表现为骨小梁体积（BV/TV）和骨小梁数量（Tb.N）减少以及骨小梁分离（Tb.S）增加。卵巢切除术后破骨细胞表面（Oc.S）和成骨细胞表面（Ob.S）的增加表明骨转换率增加。用α-生育酚或生育三烯酚治疗可防止BV/TV和Tb.N的降低以及Tb.S的增加，同时降低OC.S并增加OB. S。总之，这两种形式的维生素E能够防止由于卵巢切除术引起的骨质流失。生育三烯酚和α-生育酚在雌激素缺乏大鼠模型中对骨微结构的保护作用相似。
Postmenopausal osteoporotic bone loss occurs mainly due to cessation of ovarian function, a condition associated with increased free radicals. Vitamin E, a lipid-soluble vitamin, is a potent antioxidant which can scavenge free radicals in the body. In this study, we investigated the effects of alpha-tocopherol and pure tocotrienol on bone microarchitecture and cellular parameters in ovariectomized rats. Three-month-old female Wistar rats were randomly divided into ovariectomized control, sham-operated, and ovariectomized rats treated with either alpha-tocopherol or tocotrienol. Their femurs were taken at the end of the four-week study period for bone histomorphometric analysis. Ovariectomy causes bone loss in the control group as shown by reduction in both trabecular volume (BV/TV) and trabecular number (Tb.N) and an increase in trabecular separation (Tb.S). The increase in osteoclast surface (Oc.S) and osteoblast surface (Ob.S) in ovariectomy indicates an increase in bone turnover rate. Treatment with either alpha-tocopherol or tocotrienol prevents the reduction in BV/TV and Tb.N as well as the increase in Tb.S, while reducing the Oc.S and increasing the Ob.S. In conclusion, the two forms of vitamin E were able to prevent bone loss due to ovariectomy. Both tocotrienol and alpha-tocopherol exert similar effects in preserving bone microarchitecture in estrogen-deficient rat model.
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