Telomere length associated with the risks of high-risk and ischemic stroke in southern Chinese Han population.
Telomere length associated with the risks of high-risk and ischemic stroke in southern Chinese Han population.
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DOI：
10.18632/oncotarget.22509
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Luo D;Hou Q;Yu J;Yu D
之前的一些研究表明端粒长度与缺血性中风（IS）的风险相关。本研究的目的是进一步证实相对端粒长度（RTL）与IS风险之间的关联，特别是探讨其与中国南方汉族脑卒中高危人群风险的相关性。通过使用实时定量聚合酶链反应测定 400 名缺血性中风患者、409 名高危中风人群和 399 名健康对照者的 RTL。通过使用无条件逻辑回归评估对照组与高风险和缺血性中风风险之间的相关性。 IS 患者的 RTL 比对照组更长（中位数 1.52vs1.11，p60 岁），并且性别表明，当使用第二个三分位数作为参考时，RTL 的第一个和第二个三分位数与各组的 IS 风险相关。然而，高危卒中人群的风险增加仅出现在年龄≤60岁和女性群体的RTL前三分位数中。 RTL 与缺血性中风的风险增加有关，同时在某些特定亚群中它会增加高风险中风的风险。
Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.
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在健康、衰老和身体成分研究中，累积炎症负荷与白细胞端粒长度短有关。
影响因子：
3.7
作者：
O'Donovan A;Pantell MS;Puterman E;Dhabhar FS;Blackburn EH;Yaffe K;Cawthon RM;Opresko PL;Hsueh WC;Satterfield S;Newman AB;Ayonayon HN;Rubin SM;Harris TB;Epel ES;Health Aging and Body Composition Study
通讯作者：
Health Aging and Body Composition Study
影响因子：
3.9
作者：
Uziel, Orit;Singer, Joelle Attal;Lahav, Meir
通讯作者：
Lahav, Meir
影响因子：
--
作者：
D'Mello, Matthew J. J.;Ross, Stephanie A.;Pare, Guillaume
通讯作者：
Pare, Guillaume
DOI：
10.1136/bmj.g4227
发表时间：
2014-07-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Haycock PC;Heydon EE;Kaptoge S;Butterworth AS;Thompson A;Willeit P
通讯作者：
Willeit P
影响因子：
3.7
作者：
Jiang X;Dong M;Cheng J;Huang S;He Y;Ma K;Tang B;Guo Y
通讯作者：
Guo Y