Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
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在健康、衰老和身体成分研究中，累积炎症负荷与白细胞端粒长度短有关。
DOI：
10.1371/journal.pone.0019687
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Health Aging and Body Composition Study
中科院分区：
文献类型：
--
作者：
O'Donovan A;Pantell MS;Puterman E;Dhabhar FS;Blackburn EH;Yaffe K;Cawthon RM;Opresko PL;Hsueh WC;Satterfield S;Newman AB;Ayonayon HN;Rubin SM;Harris TB;Epel ES;Health Aging and Body Composition Study
白细胞端粒长度（LTL）是一个新兴的生物年龄标记。慢性炎症活动通常被认为是生物衰老的启动子，特别是白细胞端粒缩短。此外，端粒极短的衰老细胞产生促炎因子。然而，尽管提出了炎症活动与LTL之间的因果关系，但很少有临床证据支持它们的共变和相互作用。为了解决这个问题，我们检查了具有高水平全身炎症标志物白介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)和c反应蛋白（CRP）的个体是否增加了短期LTL的几率。我们的样本包括1962名参加健康、衰老和身体成分研究的高功能成年人（年龄范围：70-79岁）。Logistic回归分析表明，IL-6或TNF-α水平高的个体出现短期LTL的几率显著增加。此外，IL-6和TNF-α水平高的个体与不高（OR = 0.52, CI = 0.37-0.72）、只有IL-6水平高（OR = 0.57, CI = 0.39-0.83）或只有TNF-α水平高（OR = 0.67, CI = 0.46-0.99）的个体相比，短期LTL的几率明显更高，调整了各种已确定的危险因素和潜在的混杂因素。相比之下，CRP与LTL无关。结果表明，累积炎症负荷（由高水平IL-6和TNF-α联合指示）与短期LTL的几率增加有关。相反，在这组老年人中，高水平的CRP并没有伴随较短的LTL。这些数据首次大规模证明了炎症标志物与老年人群LTL之间的联系。
Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction. To address this issue, we examined if individuals with high levels of the systemic inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) had increased odds for short LTL. Our sample included 1,962 high-functioning adults who participated in the Health, Aging and Body Composition Study (age range: 70–79 years). Logistic regression analyses indicated that individuals with high levels of either IL-6 or TNF-α had significantly higher odds for short LTL. Furthermore, individuals with high levels of both IL-6 and TNF-α had significantly higher odds for short LTL compared with those who had neither high (OR = 0.52, CI = 0.37–0.72), only IL-6 high (OR = 0.57, CI = 0.39–0.83) or only TNF-α high (OR = 0.67, CI = 0.46–0.99), adjusting for a wide variety of established risk factors and potential confounds. In contrast, CRP was not associated with LTL. Results suggest that cumulative inflammatory load, as indexed by the combination of high levels of IL-6 and TNF-α, is associated with increased odds for short LTL. In contrast, high levels of CRP were not accompanied by short LTL in this cohort of older adults. These data provide the first large-scale demonstration of links between inflammatory markers and LTL in an older population.
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影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
影响因子：
37.8
作者：
Calabró, P;Willerson, JT;Yeh, ETH
通讯作者：
Yeh, ETH
影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
影响因子：
3.5
作者：
CASTELL, JV;GOMEZLECHON, MJ;HEINRICH, PC
通讯作者：
HEINRICH, PC
DOI：
10.1016/j.bbrc.2004.02.080
发表时间：
2004-04-02
影响因子：
3.1
作者：
Akiyama, M;Yamada, O;Anderson, KC
通讯作者：
Anderson, KC