Decreased leukocyte telomere length (LTL) is associated with stroke but unlikely to be causative.
Decreased leukocyte telomere length (LTL) is associated with stroke but unlikely to be causative.
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DOI：
10.1371/journal.pone.0068254
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Guo Y
中科院分区：
文献类型：
--
作者：
Jiang X;Dong M;Cheng J;Huang S;He Y;Ma K;Tang B;Guo Y
端粒长度的个体间变异是高度遗传的。白细胞端粒长度（LTL）缩短已被证明与动脉粥样硬化的过程。但LTL的遗传是否与脑卒中有关尚不清楚。这项研究的目的是测试端粒缩短是否与中风有关，以及这种联系是否主要是由于遗传或后天心血管危险因素。我们的研究重点是患者及其兄弟姐妹的中风。本研究共纳入450例受试者，其中缺血性脑卒中患者150例为病例组，非脑卒中患者的同胞150例为同胞组，正常对照组150例。通过实时聚合酶链反应测量LTL。LTL和心血管危险因素之间的关联也被确定。病例组LTL显著低于同胞组（0.92± 0.77vs1.68 ±1.24，p<0.001）和正常组（0.92± 0.77vs1.95 ±1.07，p<0.001），而同胞组与健康对照组之间无显著性差异（p = 0.330）。 端粒长度较短与高血压（p = 0.029，OR = 2.189，95%CI：1.084-4.421）、近期社会压力（p = 0.001，OR = 3.121，95%CI：1.597-6.101）、年龄（p = 0.004，OR = 1.055，95%CI：1.017-1.093）、HDL（p = 0.022，OR = 0.227，95%CI：0.064-0.810）和糖尿病（p = 0.018，OR = 3.174，95%CI：1.221-8.252）独立相关。 此外，端粒长度缩短（p = 0.017，OR = 3.996，95%CI：1.283-12.774）是病例组和同胞组中卒中的独立风险生物标志物。 目前的研究表明，LTL降低可能与缺血性卒中有关，但不太可能是病因。
Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if telomere shortening was associated with stroke and whether this association was mainly due to inheritance or acquired cardiovascular risk factors. Our study was focused on stroke in patients and their siblings. 450 subjects were recruited into this study: 150 patients with ischemic stroke as case group, 150 siblings of patients free of stroke (sibling group) and 150 healthy people as normal control. LTL was measured by real-time Polymerase Chain Reactions. The association between LTL and the cardiovascular risk factors was also determined. A significant decrease of LTL was found in case group when comparing with sibling (0.92±0.77 vs 1.68±1.24, p<0.001) and normal groups (0.92±0.77 vs 1.95±1.07, p<0.001), but no significant difference was found between sibling group and healthy control (p = 0.330). Shorter telomere length was independently associated with hypertension (p = 0.029, OR = 2.189, 95%CI:1.084–4.421), recent social pressure (p = 0.001, OR = 3.121, 95%CI:1.597–6.101), age (p = 0.004, OR = 1.055, 95%CI:1.017–1.093), HDL (p = 0.022, OR = 0.227, 95%CI:0.064–0.810) and diabetes (p = 0.018, OR = 3.174, 95%CI:1.221–8.252). Additionally, shortened length of telomere (p = 0.017, OR = 3.996, 95%CI:1.283–12.774) was an independent risk biomarker for stroke among case and sibling groups. The present study has demonstrated that decreased LTL might be associated with ischemic stroke but unlikely to be causative.
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