Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors.
Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors.
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DOI：
10.3390/ijms232314995
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发表时间：
2022-11-30
影响因子：
5.6
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中科院分区：
文献类型：
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目前的工作旨在研究急性强迫游泳 (FS) 对以下部位脑源性神经营养因子 (BDNF) 和酪氨酸激酶受体 B (trkB) 蛋白水平的影响： 腹侧被盖区 (VTA)；伏隔核 (Acb) 外壳和核心室；以及前额叶皮层的前扣带回（ACg）、前边缘（PL）和下边缘（IL）区域，这些区域是对压力引起的抑郁症的脆弱性（RLA，罗马低回避大鼠）和抵抗（RHA，罗马高回避大鼠）遗传模型的区域。我们首次报道 FS 诱导 RHA 和 RLA 大鼠中皮质边缘系统不同区域 BDNF 和 trkB 蛋白水平的快速且明显的变化。因此，（1）在 VTA 和 Acb 核心中，FS 引起 RHA 大鼠（而非 RLA 大鼠）的 BDNF- 和 trkB-LI 显着增加，而在 Acb 外壳中，未观察到跨线和治疗的 BDNF- 和 trkB-LI 显着变化； (2)RLA大鼠IL/PL皮质中BDNF-LI和ACg皮质中trkB-LI的基础水平显着低于RHA大鼠;此外，RLA大鼠中IL/PL和ACg皮质中的BDNF-和trkB-LI因FS而增加，但在RHA大鼠中则减少。这些结果提供了令人信服的证据，表明遗传背景影响压力对 BDNF/trkB 信号传导的影响，并支持以下观点：相同的压力源可能对不同大脑区域的 BDNF 表达产生不同的影响。
The present work was undertaken to investigate the effects of acute forced swimming (FS) on the levels of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (trkB) proteins in: the ventral tegmental area (VTA); the nucleus accumbens (Acb) shell and core compartments; and the anterior cingulate (ACg), prelimbic (PL) and infralimbic (IL) territories of the prefrontal cortex of genetic models of vulnerability (RLA, Roman low-avoidance rats) and resistance (RHA, Roman high-avoidance rats) to stress-induced depression. We report for the first time that FS induced very rapid and distinct changes in the levels of BDNF and trkB proteins in different areas of the mesocorticolimbic system of RHA and RLA rats. Thus, (1) in the VTA and Acb core, FS elicited a significant increase of both BDNF- and trkB-LI in RHA but not RLA rats, whereas in the Acb shell no significant changes in BDNF- and trkB-LI across the line and treatment were observed; (2) in RLA rats, the basal levels of BDNF-LI in the IL/PL cortex and of trkB-LI in the ACg cortex were markedly lower than those of RHA rats; moreover, BDNF- and trkB-LI in the IL/PL and ACg cortex were increased by FS in RLA rats but decreased in their RHA counterparts. These results provide compelling evidence that the genetic background influences the effects of stress on BDNF/trkB signaling and support the view that the same stressor may impact differently on the expression of BDNF in discrete brain areas.
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影响因子：
2.7
作者：
Cassaday, HJ;Horsley, RR;Norman, C
通讯作者：
Norman, C
影响因子：
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作者：
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通讯作者：
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DOI：
10.1126/stke.2252004re5
发表时间：
2004-03-16
期刊：
Science's STKE : signal transduction knowledge environment
影响因子：
--
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
Nikulina, E. M.
影响因子：
3.3
作者：
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通讯作者：
Williams, JT