Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited.
Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited.
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DOI：
10.1007/s00401-012-1066-5
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发表时间：
2012-12
影响因子：
12.7
通讯作者：
Dumont DJ
中科院分区：
文献类型：
--
作者：
Plate KH;Scholz A;Dumont DJ
肿瘤血管生成的细胞和分子机制及其抗血管生成肿瘤治疗的前景是当前几乎所有癌症生物学和靶向癌症治疗概念中的主要问题。目前，（1）萌芽血管生成，（2）血管共选择，（3）血管套叠，（4）血管生成拟态，（5）骨髓源性血管生成，（6）癌干细胞样细胞源性血管生成和（7）髓细胞驱动的血管生成都被认为有助于肿瘤血管生成。这些过程中的许多已经在发育性血管生成中描述;然而，这些在人类脑癌中的相对贡献和相关性仍然不清楚。临床前肿瘤模型支持萌芽血管生成、血管共选择和髓样细胞源性血管生成在胶质瘤血管形成中的作用，而其他四种机制的作用仍然存在争议且相当神秘。靶向VEGF的抗血管生成药物Avastin（贝伐单抗）已成为世界上最受欢迎的癌症药物之一。抗血管生成治疗可能导致血管正常化，因此有助于常规细胞毒性化疗。然而，临床前和临床研究表明，使用贝伐珠单抗的抗VEGF治疗也可能导致耐药胶质母细胞瘤中的促迁移表型，从而积极促进肿瘤侵袭和复发性肿瘤生长。本文就恶性胶质瘤血管生成的靶向治疗机制和肿瘤血管生成中存在争议的问题，如肿瘤干细胞源性血管生成和骨髓源性血管生成进行综述。
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) vascular intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) cancer stem-like cell-derived vasculogenesis and (7) myeloid cell-driven angiogenesis are all considered to contribute to tumor angiogenesis. Many of these processes have been described in developmental angiogenesis; however, the relative contribution and relevance of these in human brain cancer remain unclear. Preclinical tumor models support a role for sprouting angiogenesis, vascular co-option and myeloid cell-derived angiogenesis in glioma vascularization, whereas a role for the other four mechanisms remains controversial and rather enigmatic. The anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one of the most popular cancer drugs in the world. Anti-angiogenic therapy may lead to vascular normalization and as such facilitate conventional cytotoxic chemotherapy. However, preclinical and clinical studies suggest that anti-VEGF therapy using bevacizumab may also lead to a pro-migratory phenotype in therapy resistant glioblastomas and thus actively promote tumor invasion and recurrent tumor growth. This review focusses on (1) mechanisms of tumor angiogenesis in human malignant glioma that are of particular relevance for targeted therapy and (2) controversial issues in tumor angiogenesis such as cancer stem-like cell-derived vasculogenesis and bone-marrow-derived vasculogenesis.
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DOI：
10.4137/cmo.s7232
发表时间：
2011
期刊：
Clinical Medicine Insights. Oncology
影响因子：
--
作者：
Chamberlain MC
通讯作者：
Chamberlain MC
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
24
作者：
Belcik, J. Todd;Qi, Yue;Kaufmann, Beat A.;Xie, Aris;Bullens, Sherry;Morgan, Terry K.;Bagby, Susan P.;Kolumam, Ganesh;Kowalski, Joe;Oyer, Jon A.;Bunting, Stuart;Lindner, Jonathan R.
通讯作者：
Lindner, Jonathan R.
影响因子：
2.8
作者：
Broholm, H;Laursen, H
通讯作者：
Laursen, H
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.