The role of receptor binding specificity in interspecies transmission of influenza viruses.

The role of receptor binding specificity in interspecies transmission of influenza viruses.
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DOI:
10.1016/j.coviro.2012.03.003
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发表时间:
2012-04
影响因子:
5.9
通讯作者:
Kawaoka Y
Kawaoka Y
中科院分区:
医学2区
文献类型:
--
作者:
Imai M;Kawaoka Y

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甲型流感病毒感染始于血凝素(HA)糖蛋白与靶细胞表面含唾液酸受体的结合。禽流感病毒,包括禽H5 N1、H7和H9 N2病毒,偶尔可以跨越物种屏障感染人类;然而,这些病毒不会在人与人之间有效传播,部分原因可能是人类和禽流感病毒的受体结合特异性不同。禽流感病毒的HA必须适应人类的受体才能获得有效的人与人之间的传播性。在这篇综述中,我们讨论了甲型流感病毒的受体结合特异性及其在种间传播中的作用。
Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, in part, due to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.
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