Arginine impairs endothelial and executive function in older subjects with cardiovascular risk.
Arginine impairs endothelial and executive function in older subjects with cardiovascular risk.
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DOI：
10.1016/j.jash.2018.07.002
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Fisher NDL
中科院分区：
文献类型：
--
作者：
Beckman JA;Hurwitz S;Fisher NDL
神经血管耦合，即脑血流和神经元活动之间的关系，在执行功能受损的患者中减弱。在有心血管危险因素的老年受试者中，我们测试了外周血管功能可能与执行功能相关的假设，以及抗氧化剂L-精氨酸的治疗将改善血管和执行功能。纳入19例2型糖尿病和/或控制高血压的受试者。受试者接受L精氨酸或安慰剂治疗4天，这是一项随机、双盲、交叉研究。在每种情况下的第1天和第4天进行肱动脉血管功能、外周动脉眼压测量和连线试验B部分(TMTB)测试。L-精氨酸可显著降低指端反应性充血指数，与安慰剂比较差异有统计学意义(P=0.01)。通过执行功能测试，我们观察到治疗和秩序之间存在显著的交互作用。将分析限制在第一个疗程内，服用安慰剂的受试者从第1天到每天的TMTB时间减少了57.3±52.5秒，而服用精氨酸的受试者没有显著变化(6.4±18.4秒恶化，p=0.37)。此外，L-精氨酸与平均动脉压由88±9 mm Hg升至92±11 mm Hg相关，有统计学意义。L-精氨酸治疗恶化了有心血管危险因素的老年受试者的手指微血管和执行功能。这些数据进一步支持了血管和执行功能之间的联系。
Neurovascular coupling, the relationship between cerebral blood flow and neuronal activity, is attenuated in patients with impaired executive function. We tested the hypothesis that peripheral vascular function may associate with executive function in older subjects with cardiovascular risk factors, and that treatment with the antioxidant L-arginine would improve both vascular and executive function. Nineteen subjects with type 2 diabetes mellitus and/or controlled hypertension were enrolled. Subjects were treated with L-arginine or placebo for 4 days in a randomized, double-blinded cross-over study. Brachial artery vascular function, peripheral artery tonometry, and Trail Making Test Part B (TMTB) testing were performed on day 1 and day 4 during each condition. L-arginine signficiantly reduced the digital reactive hyperemia index, and the comparison of changes against placebo was significant (p=0.01). With executive function testing, we observed a significant interaction between treatment and order. Restricting the analysis to the first treatment period, subjects treated with placebo decreased their TMTB times by 57.3 ± 52.5 seconds from day 1 to day while those treated with arginine had no significant change (6.4 ± 18.4 seconds worse, p = 0.37). In addition, L-arginine was associated with increased mean arterial pressure from 88 ± 9 mm Hg to 92 ± 11 mm Hg, which trended toward significance. L-arginine treatment worsened digital microvascular and executive function in older subjects with cardiovascular risk factors. These data further support a link between vascular and executive function.
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