DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.
DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.
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DC-SIGN是人树突状细胞上的主要结核分枝杆菌受体。
DOI：
10.1084/jem.20021468
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发表时间：
2003-01-06
影响因子：
15.3
通讯作者：
Neyrolles, O
中科院分区：
文献类型：
--
作者：
Tailleux, L;Schwartz, O;Herrmann, JL;Pivert, E;Jackson, M;Amara, A;Legres, L;Dreher, D;Nicod, LP;Gluckman, JC;Lagrange, PH;Gicquel, B;Neyrolles, O
肺树突状细胞（LDCs）与结核分枝杆菌（Mycobacterium tuberculosis，TB）之间的早期相互作用被认为是建立保护性抗分枝杆菌免疫应答和确定感染结果的关键。然而，这些相互作用知之甚少，至少在分子水平上。在这里，我们表明M。结核杆菌在与最近鉴定的凝集素DC特异性细胞间粘附分子-3抓取非整联蛋白（DC-SIGN）结合后进入人单核细胞衍生的DC。与此相反，补体受体（CR）3和甘露糖受体（MR），这是主要的M。巨噬细胞（Mφs）上的结核受体在分枝杆菌与DC的结合中似乎起次要作用（如果有的话）。分枝杆菌特异性脂多糖阿拉伯甘露脂（LAM）被鉴定为DC-SIGN的关键配体。发现新鲜分离的人LDCs表达DC-SIGN，M.在结核病患者淋巴结（LN）中的CD 14 −HLA-DR+DC-SIGN+细胞中检测到结核源性物质。因此，对于被相同受体捕获的人类免疫缺陷病毒（HIV），DC-SIGN介导的M.在体内DC中的结核病可能影响细菌持久性和宿主免疫。
Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial immune response and for determining the outcome of infection. However, these interactions are poorly understood, at least at the molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast, complement receptor (CR)3 and mannose receptor (MR), which are the main M. tuberculosis receptors on macrophages (Mφs), appeared to play a minor role, if any, in mycobacterial binding to DCs. The mycobacteria-specific lipoglycan lipoarabinomannan (LAM) was identified as a key ligand of DC-SIGN. Freshly isolated human LDCs were found to express DC-SIGN, and M. tuberculosis–derived material was detected in CD14−HLA-DR+DC-SIGN+ cells in lymph nodes (LNs) from patients with tuberculosis. Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN–mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity.
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影响因子：
64.5
作者：
Geijtenbeek, TBH;Torensma, R;Figdor, CG
通讯作者：
Figdor, CG
影响因子：
4.4
作者：
Jiao, XN;Lo-Man, R;Leclerc, C
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Leclerc, C
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Lee, B;Leslie, G;Doms, RW
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Doms, RW
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通讯作者：
Modlin, RL
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56.9
作者：
Feinberg, H;Mitchell, DA;Weis, WI
通讯作者：
Weis, WI