Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats.
Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats.
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DOI：
10.1111/j.1460-9568.2009.07027.x
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Carelli RM
中科院分区：
文献类型：
--
作者：
Aragona BJ;Day JJ;Roitman MF;Cleaveland NA;Wightman RM;Carelli RM
药物寻求是显着调节药物相关的线索和环境线索和可卡因奖励之间的关联学习介导的多巴胺在丘脑核（NAc）内的传输。然而，在早期收购的线索可卡因协会的多巴胺传输从未进行过评估，因为解决线索诱发和可卡因诱发的多巴胺释放在同一个条件反射试验中的技术困难。在这里，我们使用快速扫描循环伏安法来测量亚秒内的多巴胺浓度波动的NAC核心和外壳在最初收购的线索可卡因巴甫洛夫协会。在NAc核心内，在条件反射期间开发了线索诱发的多巴胺释放。然而，在NAc壳内，预测线索似乎会导致多巴胺浓度无条件降低。可卡因的药理作用也不同的子区域之间，可卡因增加阶段性多巴胺释放事件内的NAc壳，但不是核心。因此，实时测量不仅揭示了条件神经化学反应的最初发展，而且还表现出不同的阶段性多巴胺传输模式在整个NAC子区域在收购的线索可卡因协会。
Drug seeking is significantly regulated by drug-associated cues and associative learning between environmental cues and cocaine reward is mediated by dopamine transmission within the nucleus accumbens (NAc). However, dopamine transmission during early acquisition of a cue-cocaine association has never been assessed because of the technical difficulties associated with resolving cue-evoked and cocaine-evoked dopamine release within the same conditioning trial. Here, we used fast-scan cyclic voltammetry to measure sub-second fluctuations in dopamine concentration within the NAc core and shell during the initial acquisition of a cue-cocaine Pavlovian association. Within the NAc core, cue-evoked dopamine release developed during conditioning. However, within the NAc shell, the predictive cue appeared to cause an unconditioned decrease in dopamine concentration. The pharmacological effects of cocaine also differed between sub-regions, as cocaine increased phasic dopamine release events within the NAc shell but not the core. Thus, real-time measurements not only revealed the initial development of a conditioned neurochemical response but also demonstrated differential phasic dopamine transmission patterns across NAc sub-regions during the acquisition of a cue-cocaine association.
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