Emerging knowledge of regulatory roles of D-amino acids in bacteria.
Emerging knowledge of regulatory roles of D-amino acids in bacteria.
复制标题
DOI：
10.1007/s00018-010-0571-8
复制
发表时间：
2011-03
影响因子：
8
通讯作者：
Waldor, Matthew K.
中科院分区：
文献类型：
--
作者：
Cava, Felipe;Lam, Hubert;de Pedro, Miguel A.;Waldor, Matthew K.
氨基酸的D -对映体在生物过程中被认为具有相对次要的功能。虽然L -氨基酸在自然界中明显占主导地位，但有时在非核糖体合成的蛋白质中会发现D -氨基酸，并且D -丙氨酸和D -谷氨酸经常出现在细菌的肽聚糖细胞壁中。在此，我们回顾近期的研究结果，这些结果表明D -氨基酸在细菌界具有此前未被重视的调节作用。许多不同的细菌门会合成并释放D -氨基酸，包括此前未知的D -甲硫氨酸和D -亮氨酸。这些非经典的D -氨基酸在稳定期调节细胞壁重塑，并导致老化细菌群落中的生物膜分散。阐明D -氨基酸调控细胞壁重塑和生物膜分解的机制无疑将揭示理解胞外过程如何被调控的新范式，并促使新型治疗方法的开发。
The d-enantiomers of amino acids have been thought to have relatively minor functions in biological processes. While l-amino acids clearly predominate in nature, d-amino acids are sometimes found in proteins that are not synthesized by ribosomes, and d-Ala and d-Glu are routinely found in the peptidoglycan cell wall of bacteria. Here, we review recent findings showing that d-amino acids have previously unappreciated regulatory roles in the bacterial kingdom. Many diverse bacterial phyla synthesize and release d-amino acids, including d-Met and d-Leu, which were not previously known to be made. These noncanonical d-amino acids regulate cell wall remodeling in stationary phase and cause biofilm dispersal in aging bacterial communities. Elucidating the mechanisms by which d-amino acids govern cell wall remodeling and biofilm disassembly will undoubtedly reveal new paradigms for understanding how extracytoplasmic processes are regulated as well as lead to development of novel therapeutics.
登录
查看更多内容
影响因子：
4.9
作者：
de Jonge, BLM;Gage, D;Xu, NX
通讯作者：
Xu, NX
影响因子：
3.5
作者：
BALLIO, A;BARRA, D;SIMMACO, M
通讯作者：
SIMMACO, M
影响因子：
3.6
作者：
Arias, CA;Martín-Martinez, M;Reynolds, PE
通讯作者：
Reynolds, PE
影响因子：
56.9
作者：
BODANSZKY, M;PERLMAN, D
通讯作者：
PERLMAN, D
影响因子：
4
作者：
Buynak, John D.
通讯作者：
Buynak, John D.