The crosslinking of polysaccharides with polyamines and dextran-polyallylamine antibacterial hydrogels.
The crosslinking of polysaccharides with polyamines and dextran-polyallylamine antibacterial hydrogels.
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DOI：
10.1016/j.ijbiomac.2014.08.003
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发表时间：
2015-01
影响因子：
8.2
通讯作者：
Cheng HP
中科院分区：
文献类型：
--
作者：
O'Connor NA;Abugharbieh A;Yasmeen F;Buabeng E;Mathew S;Samaroo D;Cheng HP
通过多糖与多胺的交联反应，建立了一种快速制备pH响应性水凝胶的简单的模块化方法。水凝胶的制备是通过首先使反应性较低的多糖与交联剂表氯醇反应，然后加入多胺来完成。多糖与多胺的交联提供了一种将功能性引入多糖基水凝胶中的简便方法。用多糖葡聚糖、支链淀粉和羧甲基纤维素以及用多胺聚烯丙胺和聚乙烯亚胺证明了该方法。通过FTIR和溶胀研究对水凝胶进行表征，其显示由于多胺的存在而引起的pH依赖性溶胀。也可以通过改变多糖和多胺之间的质量比来定制水凝胶。有机分析物的吸收研究表明，多胺含量影响带电底物（亚甲蓝）的吸收，而对中性底物（6-甲基香豆素）无影响。该合成方法还用于制备对大肠杆菌具有抗菌活性的水凝胶。coli和革兰氏阳性菌S.利用两亲性聚烯丙胺对金黄色葡萄球菌进行了抑菌试验。
A facile modular approach to rapidly prepare pH-responsive hydrogels by crosslinking polysaccharides with polyamines is demonstrated. Hydrogels are prepared by first reacting the less reactive polysaccharides with the cross-linker epichlorohydrin and completed by the addition of polyamines. The crosslinking of polysaccharides with polyamines provides a facile method for incorporating functionality into polysaccharide based hydrogels. This process is demonstrated with the polysaccharides dextran, pullulan and carboxymethyl cellulose and with the polyamines polyallylamine and polyethylene imine. The hydrogels were characterized by FTIR and swelling studies, which showed pH-dependent swelling due to the presence of the polyamine. The hydrogels can also be tailored by varying the mass ratio between the polysaccharide and polyamine. Absorption studies of organic analytes showed the polyamine content affecting the uptake of a charged substrate (methylene blue) and no effect on a neutral substrate (6-methyl coumarin). This synthetic method was also used to prepare hydrogels with antibacterial activity against E. coli and S. aureus by utilizing an amphiphilic polyallylamine.
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