Identification of attention-deficit hyperactivity disorder based on the complexity and symmetricity of pupil diameter.
Identification of attention-deficit hyperactivity disorder based on the complexity and symmetricity of pupil diameter.
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DOI：
10.1038/s41598-021-88191-x
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发表时间：
2021-04-19
影响因子：
4.6
通讯作者：
Toda S
中科院分区：
文献类型：
--
作者：
Nobukawa S;Shirama A;Takahashi T;Takeda T;Ohta H;Kikuchi M;Iwanami A;Kato N;Toda S
成人注意力缺陷多动障碍（ADHD）如果得不到解决，经常会导致心理/社会功能障碍。确定可靠的生物标志物将有助于诊断成人ADHD，并确保患有ADHD的成人接受治疗。瞳孔直径可以反映ADHD的固有神经活动和注意力缺陷或唤醒特征。此外，神经活动的复杂性和复杂性的不同特征与一些精神疾病有关。我们假设，分析的大小，时间模式的复杂性和瞳孔直径的不对称性之间的关系将有助于表征成人ADHD的神经系统，并结合这些功能的识别方法将简化成人ADHD的诊断。为了验证这一假设，我们评估了休息状态的成年参与者与或不注意缺陷多动障碍的海马检查瞳孔直径和时间的复杂性，使用样本熵和不对称的左右瞳孔使用传输熵。我们发现，大瞳孔直径和低时间复杂性和对称性与ADHD相关。分类器将这些因素结合起来，提高了ADHD识别的准确性。这些发现可能有助于开发诊断成人ADHD的工具。
Adult attention-deficit/hyperactivity disorder (ADHD) frequently leads to psychological/social dysfunction if unaddressed. Identifying a reliable biomarker would assist the diagnosis of adult ADHD and ensure that adults with ADHD receive treatment. Pupil diameter can reflect inherent neural activity and deficits of attention or arousal characteristic of ADHD. Furthermore, distinct profiles of the complexity and symmetricity of neural activity are associated with some psychiatric disorders. We hypothesized that analysing the relationship between the size, complexity of temporal patterns, and asymmetricity of pupil diameters will help characterize the nervous systems of adults with ADHD and that an identification method combining these features would ease the diagnosis of adult ADHD. To validate this hypothesis, we evaluated the resting state hippus in adult participants with or without ADHD by examining the pupil diameter and its temporal complexity using sample entropy and the asymmetricity of the left and right pupils using transfer entropy. We found that large pupil diameters and low temporal complexity and symmetry were associated with ADHD. Moreover, the combination of these factors by the classifier enhanced the accuracy of ADHD identification. These findings may contribute to the development of tools to diagnose adult ADHD.
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影响因子：
4.4
作者：
Takeda T;Tsuji Y;Uwatoko T;Kurita H
通讯作者：
Kurita H
影响因子：
4.5
作者：
Barnett, KJ;Corballis, MC;Kirk, IJ
通讯作者：
Kirk, IJ
影响因子：
4.7
作者：
Bast, Nico;Banaschewski, Tobias;Freitag, Christine M.
通讯作者：
Freitag, Christine M.
DOI：
10.1007/s12402-016-0208-3
发表时间：
2017-03
期刊：
Attention deficit and hyperactivity disorders
影响因子：
--
作者：
Fayyad J;Sampson NA;Hwang I;Adamowski T;Aguilar-Gaxiola S;Al-Hamzawi A;Andrade LH;Borges G;de Girolamo G;Florescu S;Gureje O;Haro JM;Hu C;Karam EG;Lee S;Navarro-Mateu F;O'Neill S;Pennell BE;Piazza M;Posada-Villa J;Ten Have M;Torres Y;Xavier M;Zaslavsky AM;Kessler RC;WHO World Mental Health Survey Collaborators
通讯作者：
WHO World Mental Health Survey Collaborators
影响因子：
4.3
作者：
Hasegawa C;Takahashi T;Yoshimura Y;Nobukawa S;Ikeda T;Saito DN;Kumazaki H;Minabe Y;Kikuchi M
通讯作者：
Kikuchi M